지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.6
- 수록면
- 77 - 84 (8page)
이용수
초록· 키워드
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Periventricular leukomalacia, specifically characterized as white matter injury, in neonates is strongly associated with the damage of pre-myelinating oligodendrocytes. Clinical data suggest that hypoxiaischemia during delivery and intrauterine or neonatal infection-inflammation are important factors in the etiology of periventricular leukomalacia including cerebral palsy, a serious case exhibiting neurobehavioral deficits of periventricular leukomalacia. In order to explore the pathophysiological mechanisms of white matter injury and to better understand how infectious agents may affect the vulnerability of the immature brain to injury, novel animal models have been developed using hypoperfusion, microbes or bacterial products (lipopolysaccharide) and excitotoxins. Such efforts have developed rat models that produce predominantly white matter lesions by adopting combined hypoxia-ischemia technique on postnatal days 1-7, in which unilateral or bilateral carotid arteries of animals are occluded (ischemia) followed by 1-2 hour exposure to 6-8% oxygen environment (hypoxia). Furthermore, low doses of lipopolysaccharide that by themselves have no adverse-effects in 7-day-old rats, dramatically increase brain injury to hypoxicischemic challenge, implying that inflammation sensitizes the immature central nervous system. Therefore, among numerous models of periventricular leukomalacia, combination of hypoxia-ischemialipopolysaccharide might be one of the most-acceptable rodent models to induce extensive white matter injury and ensuing neurobehavioral deficits for the evaluation of candidate therapeutics.
목차
Neuropathology of Infantile PVL
Etiology of Infantile PVL
Animal Models of PVL
Conclusion
Acknowledgments
References
참고문헌 (104)
참고문헌 신청
1. [학술지(정기간행물)] - Hagberg H / 2002 / Models of white matter injury: comparison of infectious, hypoxic-ischemic, and excitotoxic insults / Ment Retard Dev Disabil Res Rev 8 (2) : 30 ~ 38
2. [학술지(정기간행물)] - Nelson KB / 2000 / Infection, inflammation and the risk of cerebral palsy / Curr Opin Neurol 13 (2) : 133 ~ 139
3. [학술지(정기간행물)] - Deng W / 2008 / Progress in periventricular leukomalacia / Arch Neurol 65 (10) : 1291 ~ 1295
4. [학술지(정기간행물)] - Rezaie P / 2002 / Periventricular leukomalacia, inflammation and white matter lesions within the developing nervous system / Neuropathology 22 (3) : 106 ~ 132
5. [학술지(정기간행물)] - Volpe JJ / 2009 / Brain injury in premature infants: a complex amalgam of destructive and developmental disturbances / Lancet Neurol 8 (1) : 110 ~ 124
2. [학술지(정기간행물)] - Nelson KB / 2000 / Infection, inflammation and the risk of cerebral palsy / Curr Opin Neurol 13 (2) : 133 ~ 139
3. [학술지(정기간행물)] - Deng W / 2008 / Progress in periventricular leukomalacia / Arch Neurol 65 (10) : 1291 ~ 1295
4. [학술지(정기간행물)] - Rezaie P / 2002 / Periventricular leukomalacia, inflammation and white matter lesions within the developing nervous system / Neuropathology 22 (3) : 106 ~ 132
5. [학술지(정기간행물)] - Volpe JJ / 2009 / Brain injury in premature infants: a complex amalgam of destructive and developmental disturbances / Lancet Neurol 8 (1) : 110 ~ 124
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UCI(KEPA) : I410-ECN-0101-2013-510-000557273