지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.6
- 수록면
- 77 - 83 (7page)
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초록· 키워드
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The objective of this study was to evaluate and compare the antitumor activity of different solvent fractions (ethanol, dichloromethane, ethyl acetate, butanol and water) of the Auricularia auricula-judae 70% ethanol extract on the P388D1 macrophage and sarcoma 180 cells. A dose-dependent antitumor activity of each solvent fraction (from 0.01 ㎎/㎖ to 0.3 ㎎/㎖) was shown against both cell types. These cytotoxic effects of all the tested fractions were confirmed on the MTT and SRB assays, without statistical differences each other. IC?? value of dichloromethane fraction was 94.2 ㎍/㎖ against sarcoma 180 cells lower than any other solvent fractions. The potent antitumor effect of the dichloromethane (DCM) fraction was also found against solid tumor in BALB/c mice. The splenomegaly and higher splenic index were found in tumor-bearing mice, with the DCM fraction returning to the negative control values. Thus, the results indicated the dichloromethane fraction may have potential ingredients as antitumor candidates.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
ACKNOWLEDGMENT
REFERENCES
참고문헌 (14)
참고문헌 신청
Ait Mbarek, L. / 2007 / Anti-tumor properties ofblackseed (Nigella sativa L.) extracts / Braz. J. Med. Biol. Res 40:839~847
Chen, G. / 2008 / Effect of polysaccharide from Auriculariaauricula on blood lipid metabolism and lipoprotein lipase activityof ICR mice fed a cholesterol-enriched diet / J. Food. Sci 73:103~108
Henriksson, E. / 2006 / Differences in estimates of cisplatininducedcell kill in vitro between colorimetric and cell count/colony assays / In. Vitro. Cell. Dev. Biol. Anim 42:320~323
Jagetia, G.C / 2006 / Evaluation of cytotoxic effectsof dichloromethane extract of guduchi (Tinospora cordifoliaMiers ex Hook f & Thoms) on cultured HeLa cells / Evid BasedComplement Alternat Med 3:267~272
Lee, Y.L. / 2003 / Oral administration of Agaricusblazei (H1 strain) inhibited tumor growth in a sarcoma 180inoculation model / Exp. Anim 52:371~375
Chen, G. / 2008 / Effect of polysaccharide from Auriculariaauricula on blood lipid metabolism and lipoprotein lipase activityof ICR mice fed a cholesterol-enriched diet / J. Food. Sci 73:103~108
Henriksson, E. / 2006 / Differences in estimates of cisplatininducedcell kill in vitro between colorimetric and cell count/colony assays / In. Vitro. Cell. Dev. Biol. Anim 42:320~323
Jagetia, G.C / 2006 / Evaluation of cytotoxic effectsof dichloromethane extract of guduchi (Tinospora cordifoliaMiers ex Hook f & Thoms) on cultured HeLa cells / Evid BasedComplement Alternat Med 3:267~272
Lee, Y.L. / 2003 / Oral administration of Agaricusblazei (H1 strain) inhibited tumor growth in a sarcoma 180inoculation model / Exp. Anim 52:371~375
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UCI(KEPA) : I410-ECN-0101-2013-513-000636830