지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.6
- 수록면
- 61 - 70 (10page)
이용수
초록· 키워드
오류제보하기
Brominated flame retardants (BFRs) are present in many consumer products ranging from fabrics to plastics and electronics. Wide use of flame retardants can pose an environmental hazard, which makes it important to determine the mechanism of their toxicity. In the present study, dose-dependent toxicity of tetrabromobisphenol A (TBBPA), a flame retardant, was examined in male prepubertal rats (postnatal day 18) treated orally with TBBPA at 0, 125, 250 or 500 ㎎/㎏ for 30 days. There were no differences in body weight gain between the control and TBBPA-treated groups. However, absolute and relative liver weights were significantly increased in high dose of TBBPA-treated groups. TBBPA treatment led to significant induction of CYP2B1 and constitutive androstane receptor (CAR) expression in the liver. In addition, serum thyroxin (T4) concentration was significantly reduced in the TBBPA treated group. These results indicate that repeated exposure to TBBPA induces drug-metabolising enzymes in rats through the CAR signaling pathway. In particular, TBBPA efficiently produced reactive oxygen species (ROS) through CYP2B1 induction in rats. We measured 8-hydroxy-2’-deoxyguanosine (8-OHdG), a biomarker of DNA oxidative damage, in the kidney, liver and testes of rats following TBBPA treatment. As expected, TBBPA strongly induced the production of 8-OHdG in the testis and kidney. These observations suggest that TBBPA-induced target organ toxicity may be due to ROS produced by metabolism of TBBPA in Sprague-Dawley rats.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
ACKNOWLEDGEMENTS
REFERENCES
참고문헌 (43)
참고문헌 신청
Alaee, M. / 2003 / An overviewof commercially used brominated flame retardants, theirapplications, their use patterns in different countries/regions andpossible modes of release / Environ. Int 29:683~689
Cariou, R. / 2008 / Exposure assessment of French womenand their newborns to tetrabromobisphenol-A: occurrence measurementsin maternal adipose tissue, serum, breast milk andcord serum / Chemosphere 73:1036~1041
Chu, S. / 2005 / Simultaneousdetermination of tetrabromobisphenol A, tetrachlorobisphenolA, bisphenol A and other halogenated analogues in sedimentand sludge by high performance liquid chromatography-electrospraytandem mass spectrometry / J. Chromatogr. A 1097:25~32
Darnerud,P.O / 2003 / Toxic effects of brominated flame retardantsin man and in wildlife / Environ. Int 29:841~853
de Wit,C.A / 2002 / An overview of brominated flame retardantsin the environment / Chemosphere 46:583~624
Cariou, R. / 2008 / Exposure assessment of French womenand their newborns to tetrabromobisphenol-A: occurrence measurementsin maternal adipose tissue, serum, breast milk andcord serum / Chemosphere 73:1036~1041
Chu, S. / 2005 / Simultaneousdetermination of tetrabromobisphenol A, tetrachlorobisphenolA, bisphenol A and other halogenated analogues in sedimentand sludge by high performance liquid chromatography-electrospraytandem mass spectrometry / J. Chromatogr. A 1097:25~32
Darnerud,P.O / 2003 / Toxic effects of brominated flame retardantsin man and in wildlife / Environ. Int 29:841~853
de Wit,C.A / 2002 / An overview of brominated flame retardantsin the environment / Chemosphere 46:583~624
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UCI(KEPA) : I410-ECN-0101-2013-513-000636774