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논문 기본 정보

자료유형
학술저널
저자정보
이상윤 (대구한의대학교) 서부일 (대구한의대학교) 박지하 (대구한의대학교) 노성수 (대구한의대학교) 김대준 (대구한의대학교)
저널정보
한국한의학연구원 한국한의학연구원 논문집 한국한의학연구원논문집 제17권 제1호
발행연도
2011.4
수록면
153 - 165 (13page)

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초록· 키워드

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Objectives : The present study had been undertaken to investigate the effects of Ligustri Lucidi Fructus Extract and Vici Herba Extract on treatment of osteoporosis in ovariectomized rats.
Method : In this experiment, the rats were ovariectomized. Rats were individually administered by water extract from Ligustri Lucidi Fructus or Vici Herba(dose:1㎖/100g, 2times/day). The levels of bone mineral density, serum components, urinary components, bony components, body weight and uterus weight were measured.
Results : The levels of spinal and femoral bone mineral density(BMD) were significantly increased in comparison with OVX group at 8 weeks after administration in Vici Herba group. The levels of serum osteocalcin showed significant decrease in comparison with OVX group at 4 weeks after administration in Ligustri Lucidi Fructus and Vici Herba group. The levels of serum ALP and phosphorus showed significant decrease in comparison with OVX group at 4, 8 weeks in after administration in Ligustri Lucidi Fructus and Vici Herba group. The levels of urinary deoxypyridinoline showed significant decrease in comparison with OVX group in Ligustri Lucidi Fructus group. The levels of fibula-tibial ash weight showed significant increase in comparison with OVX group after administration in Ligustri Lucidi Fructus group. The levels of body weight were significantly decreased in comparison with OVX group at 4 weeks after administration in Ligustri Lucidi Fructus group and at 4, 8 weeks after administration in Vici Herba group. The levels of uterus weight were not significantly increased in comparison with OVX group in Ligustri Lucidi Fructus and Vici Herba group.
Conclusion : Reviewing these experimetal results, it appeared that Ligustri Lucidi Fructus and Vici Herba had efficacy on treatment of osteoporosis.

목차

Ⅰ. 緖論
Ⅱ. 實驗
Ⅲ. 實驗成績
Ⅳ. 考察
Ⅴ. 結論
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