지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Tumor angiogenesis, which is essential for tumor growth and tumor metastasis, depends on angiogenic factors produced by tumor cells and/or infiltrating cells such as endothelial cells and immune cells in tumor tissue. Previously, we reported that licochalcone A (LicA), an important bioactive compound of Glycyrrhiza inflate, suppresses angiogenesis, tumor growth and metastasis. In this study, we evaluated the effect of LicA on angiogenin production in colon cancer cells because angiogenin is an essential factor to regulate angiogenesis and tumor progression. When we examined the angiogenin levels in three human colon cancer cells, HT-29, SW480 and Caco-2, LicA treatment significantly reduced the amounts of angiogenin among three cancer cell lines. In an in vivo study in which mice were implanted with HT-29 cells, oral administration of LicA reduced angiogenin in tumor tissues when compared with vehicle-administered mice. These results suggest that reduced angiogenin in response to LicA treatment may play essential role to inhibit tumor growth, angiogenesis as well as metastasis.
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참고문헌 (10)
참고문헌 신청
Adams SA / 1999 / The angiogenins: an emerging family of ribonuclease related proteins with diverse cellular functions / Angiogenesis 3:189~199
Etoh T / 2000 / Angiogenin expression in human colorectal cancer: the role of focal macrophage infiltration / Clin Cancer Res 6:3545~3551
Fett JW / 1985 / Isolation and characterization of angiogenin, an angiogenic protein from human carcinoma cells / Biochemistry 24:5480~5486
Kao RY / 2002 / A small-molecule inhibitor of the ribonucleolytic activity of human angiogenin that possesses antitumor activity / Proc Natl Acad Sci USA 99:10066~10071
Kim JK / 2010 / Antitumor and antimetastatic effects of licochalcone A in mouse models / J Mol Med 88:829~838
Etoh T / 2000 / Angiogenin expression in human colorectal cancer: the role of focal macrophage infiltration / Clin Cancer Res 6:3545~3551
Fett JW / 1985 / Isolation and characterization of angiogenin, an angiogenic protein from human carcinoma cells / Biochemistry 24:5480~5486
Kao RY / 2002 / A small-molecule inhibitor of the ribonucleolytic activity of human angiogenin that possesses antitumor activity / Proc Natl Acad Sci USA 99:10066~10071
Kim JK / 2010 / Antitumor and antimetastatic effects of licochalcone A in mouse models / J Mol Med 88:829~838
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UCI(KEPA) : I410-ECN-0101-2012-510-004465576