지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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In this study, we evaluated the protective effects of supercritical extracts and two step ethanol extracts after supercritical extraction from Schizandra chinensis on antioxidant activities and oxidative DNA and cell damages. Supercritical extracts removed DPPH (1,1-diphenyl-2-picryldrazyl) radical by 85.5% at 200 μg/ml, but showed low activities of scavenging and chelating the hydroxyl radical and ferrous iron. However, two step ethanol extracts showed low activities of scavenging the DPPH radical, but removed the hydroxyl radical by 86% at 200 μg/ml. In addition, we tested the activities of extracts for reducing hydroxyl radical-induced DNA and cell damage. Two step ethanol extracts showed protective effect against the oxidative DNA damage by reducing DNA segmentation, inhibiting DNA migration and decreasing the expression of phospho-H2AX. Also, two step ethanol extracts showed protective effect against the oxidative cell damage by inhibiting lipid peroxidation and increasing the expression of p21 protein. Taken together, we suggest that two step ethanol extracts from S. chinensis have a role as useful inhibitors against oxidative damages.
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REFERENCES
참고문헌 (23)
참고문헌 신청
1. [학술지(정기간행물)] - Barzilai A / 2004 / DNA damage responses to oxidative stress / DNA Repair 3 : 1109 ~ 1115
2. [학술지(정기간행물)] - Chan WKM / 1994 / EPR spintrapping studies of the hydroxyl radical scavenging activity of carnosine and related dipeptides / J Agric Food Chem 42 : 1407 ~ 1410
3. [학술지(정기간행물)] - Cho ES / 2008 / Cocoa procyanidins protect PC12 cells from hydrogen-peroxide-induced apoptosis by inhibiting activation of p38 MAPK and JNK / MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS 640 : 123 ~ 130
4. [학술지(정기간행물)] - 최수임 / 2003 / 생약재 추출물의 hyaluronidase 저해 및 라디칼 소거 활성 검색 / KSBB Journal 18 (4) : 282 ~ 288
5. [학술지(정기간행물)] - Frankel EN / 1996 / Antioxidants in lipid foods and their impact on food quality / Food Chem 57 : 51 ~ 55
2. [학술지(정기간행물)] - Chan WKM / 1994 / EPR spintrapping studies of the hydroxyl radical scavenging activity of carnosine and related dipeptides / J Agric Food Chem 42 : 1407 ~ 1410
3. [학술지(정기간행물)] - Cho ES / 2008 / Cocoa procyanidins protect PC12 cells from hydrogen-peroxide-induced apoptosis by inhibiting activation of p38 MAPK and JNK / MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS 640 : 123 ~ 130
4. [학술지(정기간행물)] - 최수임 / 2003 / 생약재 추출물의 hyaluronidase 저해 및 라디칼 소거 활성 검색 / KSBB Journal 18 (4) : 282 ~ 288
5. [학술지(정기간행물)] - Frankel EN / 1996 / Antioxidants in lipid foods and their impact on food quality / Food Chem 57 : 51 ~ 55
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UCI(KEPA) : I410-ECN-0101-2012-510-004465596