지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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In the present study, we investigated whether volatile organic compounds induce inflammatory response in human T lymphocytes by evaluating the alteration of inflammatory cytokines. Volatile organic compounds such as formaldehyde, o-xylene, benzene, and hydroquinone have no cytotoxic effects on Jurkat T cells at a high concentration of 50 μM for 48 h. IL-2, IL-4, IL-13, TNF-α and IFN-γ were increased after the treatment with volatile organic compounds, although alteration of cytokines is different among volatile organic compounds. LPS as a positive control increased the secretion of IL-2, IL-4, IL-13, TNF-α and IFN-γ. MCP-1 and CCL17 (thymus and activation-regulated chemokine, TARC) were weakly increased after the treatment with volatile organic compounds but the amount of the increased cytokine was below 20 pg/ml. These results suggest that the measurement of cytokine in Jurkat T cells may be used as a useful method for evaluating the toxicity of volatile organic compounds in immune response.
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REFERENCES
참고문헌 (15)
참고문헌 신청
Bernstein JA / 2008 / The health effects of nonindustrial indoor air pollution / J Allergy Clin Immunol 121:585~591
Curtsinger JM / 2010 / Mescher MF. Inflammatory cytokines as a third signal for T cell activation / Curr Opin Immunol 22:333~340
Golding BT / 1999 / Possible mechanisms of carcinogenesis after exposure to benzene / IARC Scientific Pub 150:75~88
Kim YJ / 2009 / Risk assessment of hydroquinone, differential responses of cell growth and lethality correlated to hydroquinone concentration / J Toxicol Environ Health A 72:1272~1278
Li Q / 1997 / Differential inhibition of DNA synthesis in human T cells by the cigarette tar components hydroquinone and catechol / Fundam Appl Toxicol 38:148~165
Curtsinger JM / 2010 / Mescher MF. Inflammatory cytokines as a third signal for T cell activation / Curr Opin Immunol 22:333~340
Golding BT / 1999 / Possible mechanisms of carcinogenesis after exposure to benzene / IARC Scientific Pub 150:75~88
Kim YJ / 2009 / Risk assessment of hydroquinone, differential responses of cell growth and lethality correlated to hydroquinone concentration / J Toxicol Environ Health A 72:1272~1278
Li Q / 1997 / Differential inhibition of DNA synthesis in human T cells by the cigarette tar components hydroquinone and catechol / Fundam Appl Toxicol 38:148~165
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UCI(KEPA) : I410-ECN-0101-2012-510-004465632