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논문 기본 정보

자료유형
학술저널
저자정보
Hye-Young Sung (대구대학교) Young-Sun Choi (대구대학교)
저널정보
한국영양학회 Nutrition Research and Practice Nutrition Research and Practice Vol.2 No.2
발행연도
2008.6
수록면
55 - 61 (7page)

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We investigated the combinatorial effects of different doses of dietary soy isoflavones (SI) and fructooligosaccharide (FOS) in a rat model of colon cancer. We hypothesized that increased bioavailability of SI metabolites due to dietary FOS may increase production of bioactive equol and affect colon carcinogenesis in a dose-dependent manner. Sprague-Dawley male rats were injected with 12-dimethylhydrazine (DMH) and were provided experimental diets that contained 0, 10, 50, 150, or 500 ㎎ SI per ㎏ of diet and 6% FOS for 12 weeks. The number of aberrant crypt foci (ACF) and the expression of cyclooxygenase-2 (COX-2) in colonic tissues were significantly decreased in the 6% FOS-fed groups compared to the control group. Gut transit time and fecal pH were significantly lower, and fecal concentrations of bifidobacteria were increased with 6% FOS. However, dietary SI supplementation in combination with 6% dietary FOS did not affect ACF formation or COX-2 expression. Plasma equol concentrations were dose-dependently increased by supplementation of SI up to 500 ㎎/㎏ of diet. In conclusion, SI supplementation up to 500 ㎎/㎏ of diet appeared to have no additive beneficial effects in rats with chemically-induced colon cancer that were fed 6% FOS, although plasma equol was dose-dependently increased.

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Abstract
Introduction
Methods and Materials
Results
Discussion
Literature cited

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UCI(KEPA) : I410-ECN-0101-2012-594-004461207