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Temperature gradient focusing (TGF) of analytes via Joule heating is achieved when electric field is applied along a microchannel of varying width. The effect of varying width of the microchannel for the focusing performance of the device was numerically studied. The governing equations were implemented into a quasi-1D numerical model along a microchannel. The validity of the numerical model was verified by a comparison between numerical and experimental results. The distributions of temperature, velocity, and concentration along a microchannel were predicted by the numerical results. The narrower middle width and wider outside width of the channel having the fixed length contribute to improve the focusing performance of the device. However, too narrow middle width of the channel generates a higher temperature which can cause the problems including sample denaturation and buffer solution boiling. Therefore, the channel geometry should be optimized to prevent these problems. The optimal widths of the microchannel for the improvement on TGF were proposed and this model can be easily applied to lab-on-a-chip (LOC) applications where focusing is required based on its simple design.
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ABSTRACT
1. 서론
2. 온도기울기농축(TGF) 원리
3. 수치해석 방법
4. 수치해석 결과
5. 결론
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참고문헌
참고문헌 (21)
참고문헌 신청
1. [학술지(정기간행물)] - Khandurina, J. / 1999 / Microfabricated Porous Membrane Structure for Sample Concentration and Electrophoretic Analysis / Analytical Chemistry 71 (9) : 1815 ~ 1819
2. [학술지(정기간행물)] - Hatch, A. V. / 2006 / Integrated Preconcentration SDS-PAGE of Proteins in Microchips Using Photopatterned Cross-Linked Polyacrylamide Gels / Analytical Chemistry 78 (14) : 4976 ~ 4984
3. [학술지(정기간행물)] - Wang, Y. C. / 2005 / Million-fold Preconcentration of Proteins and Peptides by Nanofluidic Filter / Analytical Chemistry 77 (14) : 4293 ~ 4299
4. [학술지(정기간행물)] - Kim, S. M. / 2006 / Electrokinetic Protein Preconcentration Using a Simple Glass/Poly(dimethylsiloxane) Microfluidic Chip / Analytical Chemistry 78 (14) : 4779 ~ 4785
5. [학술지(정기간행물)] - Yu, C. / 2001 / Monolithic Porous Polymer for On-Chip Solid- Phase Extraction and Preconcentration Prepared by Photoinitiated in Situ Polymerization within a Microfluidic Device / Analytical Chemistry 73 (21) : 5088 ~ 5096
2. [학술지(정기간행물)] - Hatch, A. V. / 2006 / Integrated Preconcentration SDS-PAGE of Proteins in Microchips Using Photopatterned Cross-Linked Polyacrylamide Gels / Analytical Chemistry 78 (14) : 4976 ~ 4984
3. [학술지(정기간행물)] - Wang, Y. C. / 2005 / Million-fold Preconcentration of Proteins and Peptides by Nanofluidic Filter / Analytical Chemistry 77 (14) : 4293 ~ 4299
4. [학술지(정기간행물)] - Kim, S. M. / 2006 / Electrokinetic Protein Preconcentration Using a Simple Glass/Poly(dimethylsiloxane) Microfluidic Chip / Analytical Chemistry 78 (14) : 4779 ~ 4785
5. [학술지(정기간행물)] - Yu, C. / 2001 / Monolithic Porous Polymer for On-Chip Solid- Phase Extraction and Preconcentration Prepared by Photoinitiated in Situ Polymerization within a Microfluidic Device / Analytical Chemistry 73 (21) : 5088 ~ 5096
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UCI(KEPA) : I410-ECN-0101-2012-554-004201452