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논문 기본 정보

자료유형
학술저널
저자정보
Myoung-Nam Woo (경북대학교) Seon-Min Jeon (경북대학교) Hye-Jin Kim (경북대학교) Ji-Young Yeo (경북대학교) Tae-Youl Ha (한국식품연구원) Myung-Sook Choi (경북대학교)
저널정보
한국영양학회 Nutritional Sciences Nutritional Sciences Vol.9 No.4
발행연도
2006.11
수록면
248 - 258 (11page)

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The objective of this study was to investigate the effects of supplementation of an antiobese functional formula(FC-GT) on body weight and lipid metabolism in rats fed a high-fat diet. Three groups of male Sprague-Dawley rats were fed different diets for 6 weeks: normal control (NC), high-fat (HF), and high-fat supplemented with powdered antiobese functional formula (FC-GT) (5%, wt/wt) groups. Although body weight was not significantly different among the groups, relative weights of epididymal and perirenal white adipose tissues were significantly lower in the FC-GT group than in the HF group. FC-GT supplementation significantly lowered the plasma total cholesterol and triglyceride concentrations, whereas it elevated the ratio of HDL-C/total-C and improved the atherogenic index. Hepatic cholesterol and triglyceride concentrations were significantly lowered in the FC-GT group compared to the HF group. The accumulation of hepatic lipid droplets and the epididymal white adipocyte size of the FC-GT group were diminished compared to the HF group. Hepatic HMG-CoA reductase activity was significantly lower in the FC-GT group than in the HF group. Plasma GPT activity was significantly lowered in the FC-GT group compared to the HF group. Additionally, fecal weight was significantly increased in the FC-GT group than in the HF group. In addition, contents of fecal triglyceride and cholesterol were significantly higher in the FC-GT group compared to the other groups. The antioxidant activities of hepatic SOD, CAT, and GR were significantly increased in the FC-GT group compared to the HF group. Hepatic TBARS and plasma TBARS levels were significantly lowered in the FC-GT group compared to the NC group. Accordingly, we conclude that supplementation of FC-GT improves plasma and hepatic lipid levels in high-fat fed rats.

목차

INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
Literature Cited

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UCI(KEPA) : I410-ECN-0101-2012-594-004194270