지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Myelin basic protein (MBP), a major structural protein of the myelin, is thought to be important for the maintenance of myelin in the central nervous system (CNS). We investigated the effect of maternal folic acid nutritional status on the folate level and the synthesis of MBP in the offspring. In order to test this hypothesis, female Sprague-Dawley rats were fed either folic acid sufficient (8 ㎎/㎏ diet) or deficient (0 ㎎/㎏ diet) diet from 2 wks prior to the mating throughout the entire pregnancy, lactation and weaning period. We examined plasma folate level by the radioimmunoassay and homo-cysteine level by HPLC, respectively. The MBP expression was measured by the western blot analysis. The maternal folic acid deficiency decreased plasma folate level with a concomitant increase in plasma homo-cysteine level in their offspring. The maternal folic acid deficiency decreased hepatic levels of SAM and SAM/SAH ratio with a concomitant increase in hepatic levels of SAH and the MBP expression of spinal cord in their offspring at 7 wks of age. These results suggest that maternal folic acid nutritional status affect plasma folate and homo-cysteine level in their offspring. Moreover, the maternal folic acid deficiency might inhibit the MBP expression of the spinal cord and disrupt many other vital CNS reactions in their offspring. (Korean J Nutrition 40(2): 130~137 ,2007)
목차
ABSTRACT
서론
연구방법
연구결과
고찰
요약 및 결론
Literature cited
참고문헌 (30)
참고문헌 신청
Durga J , 2005 , Low concentrations of folate, not hyperhomocysteinemia, are associated with carotid intima-media thickness (2) : 285 ~ 292
Faurschou M , 2000 , High prevalence of hyperhomocysteinemia due to marginal deficiency of cobalamin or folate in chronic myeloproliferative disorders : 136 ~ 140
Allen RH , 1998 , Relevance of vitamins, homocysteine and other metabolites in neuropsychiatric disorders (2) : 122 ~ 126
Kruman II , 2002 , Folic acid deficiency and homocysteine impair DNA repair in hippocampal neurons and sensitize them to amyloid toxicity in experimental models of Alzheimer’s disease (5) : 1752 ~ 1762
Burgoon JM , 2002 , Investigation of the effects of folate deficiency on embryonic development through the establishment of a folate deficient mouse model (5) : 219 ~ 227
Faurschou M , 2000 , High prevalence of hyperhomocysteinemia due to marginal deficiency of cobalamin or folate in chronic myeloproliferative disorders : 136 ~ 140
Allen RH , 1998 , Relevance of vitamins, homocysteine and other metabolites in neuropsychiatric disorders (2) : 122 ~ 126
Kruman II , 2002 , Folic acid deficiency and homocysteine impair DNA repair in hippocampal neurons and sensitize them to amyloid toxicity in experimental models of Alzheimer’s disease (5) : 1752 ~ 1762
Burgoon JM , 2002 , Investigation of the effects of folate deficiency on embryonic development through the establishment of a folate deficient mouse model (5) : 219 ~ 227
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UCI(KEPA) : I410-ECN-0101-2012-594-004191704