지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.3
- 수록면
- 111 - 123 (13page)
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To investigate the effects of repeated immobilization-stress challenge on the the hypothalamic?pituitary?adrenal axis, the genomic transcriptome in the adrenal cortex of immobilization-stressed mouse was analyzed by using a cDNA microarray. Mice were subjected to immobilization stress for 2 h per day for 5 consecutive d. With a 4.0-fold cutoff of arbitrary criteria, the expression levels of 168 out of 41,174 genes were signifi cantly modulated in the adrenal cortex by stress when comparing the control and experimental groups. These genes were related to apoptosis, cell cycle, immune response, inflammatory responses, and signal transduction, and thus may be used as potential targets for the development of therapeutics for chronic stress or depression. Six significant genes among these were selected for real time polymerase chain reaction analysis to confi rm the change of their expression levels. The gene for phospho 1 was also further investigated because its expression showed the greatest fold-change.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
ACKNOWLEDGEMENTS
REFERENCES
참고문헌 (34)
참고문헌 신청
1. [학술지(정기간행물)] - Padgett DA / 2003 / How stress infl uences the immune response / Trends Immunol 24 : 444 ~ 448
2. [학술지(정기간행물)] - Cannon WB / 1929 / Organization for physiological homeostasis / Physiol Rev 9 : 399 ~ 431
3. [학술지(정기간행물)] - Pacak K / 2001 / Stressor specifi city of central neuroendocrine responses: implications for stress-related disorders / Endocr Rev 22 : 502 ~ 548
4. [학술지(정기간행물)] - Yun SJ / 2002 / Immobilization stress induces the expression of alphaB-crystallin in rat hippocampus: implications of glial activation in stress-mediated hippocampal degeneration / Neurosci Lett 324 : 45 ~ 48
5. [학술지(정기간행물)] - Rage F / 2002 / Immobilization stress rapidly modulates BDNF mRNA expression in the hypothalamus of adult male rats / Neuroscience 112 : 309 ~ 318
2. [학술지(정기간행물)] - Cannon WB / 1929 / Organization for physiological homeostasis / Physiol Rev 9 : 399 ~ 431
3. [학술지(정기간행물)] - Pacak K / 2001 / Stressor specifi city of central neuroendocrine responses: implications for stress-related disorders / Endocr Rev 22 : 502 ~ 548
4. [학술지(정기간행물)] - Yun SJ / 2002 / Immobilization stress induces the expression of alphaB-crystallin in rat hippocampus: implications of glial activation in stress-mediated hippocampal degeneration / Neurosci Lett 324 : 45 ~ 48
5. [학술지(정기간행물)] - Rage F / 2002 / Immobilization stress rapidly modulates BDNF mRNA expression in the hypothalamus of adult male rats / Neuroscience 112 : 309 ~ 318
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UCI(KEPA) : I410-ECN-0101-2012-524-004215890