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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.3
- 수록면
- 92 - 103 (12page)
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Ginseng has been used as a general tonic agent to invigorate human body. In the present study, we isolated novel glycolipoproteins from ginseng that activate Ca²?-activated Cl- channel (CaCC) in Xenopus oocytes and transiently increase intracellular free Ca²? concentration ([Ca²?]<SUB>i</SUB>) in mouse Ehrlich ascites tumor cells. We named the active ingredients as gintonin. Gintonin exists in at least six different forms. The native molecular weight of gintonin is about 67 kDa but its apparent molecular weight is about 13 kDa, indicating that gintonin might be a pentamer. Gintonin is rich in hydrophobic amino acids. Its main carbohydrates are glucose and glucosamine. Its lipid components are linoleic, palmitic, oleic, and stearic acids. Gintonin actions were blocked by U73122, a phospholipase C inhibitor, 2-aminoethxydiphenyl borate, an inositol 1,4,5-trisphosphate receptor antagonist, or bis (o-aminophenoxy) ethane-N,N,N0,N0-tetracetic acid acetoxymethyl ester, a membrane permeable Ca²? chelator. In the present study, we for the fi rst time isolated novel gintonin and showed the signaling pathways on gintonin-mediated CaCC activations and transient increase of [Ca²?]<SUB>i</SUB>. Since [Ca²?]<SUB>i</SUB> as a second messenger plays a pivotal role in the regulation of diverse Ca²?-dependent intracellular signal pathways, gintonin-mediated regulations of [Ca²?]<SUB>i</SUB> might contribute to biological actions of ginseng.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
ACKNOWLEDGEMENTS
REFERENCES
참고문헌 (25)
참고문헌 신청
1. [학술지(정기간행물)] - Nah SY / 1997 / Ginseng: recent advances and trends / Korean J Ginseng Sci 21 : 1 ~ 12
2. [학술지(정기간행물)] - Shibata S / 1965 / Studies on saponins and sapogenins of ginseng: the structure of panaxatriol / Tetrahedron Lett 42 : 207 ~ 213
3. [학술지(정기간행물)] - Wagner-Jauregg T / 1962 / On panaxol, a new constituent of “red” ginseng root / Pharm Acta Helv 37 : 352 ~ 359
4. [학술지(정기간행물)] - Kanzaki T / 1998 / Role of transforming growth factor-beta pathway in the mechanism of wound healing by saponin from Ginseng Radix Rubra / Br J Pharmacol 125 : 255 ~ 262
5. [학술지(정기간행물)] - Choi S / 2001 / A novel activation of Ca(2+)-activated Cl(-) channel in Xenopus oocytes by Ginseng saponins: evidence for the involvement of phospholipase C and intracellular Ca(2+) mobilization / Br J Pharmacol 132 : 641 ~ 648
2. [학술지(정기간행물)] - Shibata S / 1965 / Studies on saponins and sapogenins of ginseng: the structure of panaxatriol / Tetrahedron Lett 42 : 207 ~ 213
3. [학술지(정기간행물)] - Wagner-Jauregg T / 1962 / On panaxol, a new constituent of “red” ginseng root / Pharm Acta Helv 37 : 352 ~ 359
4. [학술지(정기간행물)] - Kanzaki T / 1998 / Role of transforming growth factor-beta pathway in the mechanism of wound healing by saponin from Ginseng Radix Rubra / Br J Pharmacol 125 : 255 ~ 262
5. [학술지(정기간행물)] - Choi S / 2001 / A novel activation of Ca(2+)-activated Cl(-) channel in Xenopus oocytes by Ginseng saponins: evidence for the involvement of phospholipase C and intracellular Ca(2+) mobilization / Br J Pharmacol 132 : 641 ~ 648
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UCI(KEPA) : I410-ECN-0101-2012-524-004215870