지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.3
- 수록면
- 86 - 91 (6page)
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초록· 키워드
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Ginsenoside (G)-F1 is an enzymatic metabolite generated from G-Rg1. Although this metabolite has been reported to suppress platelet aggregation and to reduce gap junction-mediated intercellular communication, the modulatory activity of G-F1 on the functional role of skin-derived cells has not yet been elucidated. In this study, we evaluated the regulatory role of G-F1 on the cellular responses of B16 melanoma cells. G-F1 strongly suppressed the proliferation of B16 cells up to 60% at 200 μg/mL, while only diminishing the viability of HEK293 cells up to 30%. Furthermore, G-F1 remarkably induced morphological change and clustering of B16 melanoma cells. The melanin production of B16 cells was also significantly blocked by G-F1 up to 70%. Interestingly, intracellular signaling events involved in cell proliferation, migration, and morphological change were up-regulated at 1 h incubation but down-regulated at 12 h. Therefore, our results suggest that G-F1 can be applied as a novel anti?skin cancer drug with anti-proliferative and anti-migration features.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
REFERENCES
참고문헌 (24)
참고문헌 신청
1. [학술지(정기간행물)] - Meyskens FL Jr / 2001 / Redox regulation in human melanocytes and melanoma / Pigment Cell Res 14 : 148 ~ 154
2. [학술지(정기간행물)] - Wood JM / 2006 / Melanocortins in human melanocytes / Cell Mol Biol 52 : 75 ~ 78
3. [학술지(정기간행물)] - Slominski A / 2001 / Malignant melanoma / Arch Pathol Lab Med 125 : 1295 ~ 1306
4. [학술지(정기간행물)] - Hasani-Ranjbar S / 2009 / A systematic review of the effi cacy and safety of herbal medicines used in the treatment of obesity / World J Gastroenterol 15 : 3073 ~ 3085
5. [학술지(정기간행물)] - Hasegawa H / 2004 / Proof of the mysterious effi cacy of ginseng: basic and clinical trials: metabolic activation of ginsenoside: deglycosylation by intestinal bacteria and esterifi - cation with fatty acid / J Pharmacol Sci 95 : 153 ~ 157
2. [학술지(정기간행물)] - Wood JM / 2006 / Melanocortins in human melanocytes / Cell Mol Biol 52 : 75 ~ 78
3. [학술지(정기간행물)] - Slominski A / 2001 / Malignant melanoma / Arch Pathol Lab Med 125 : 1295 ~ 1306
4. [학술지(정기간행물)] - Hasani-Ranjbar S / 2009 / A systematic review of the effi cacy and safety of herbal medicines used in the treatment of obesity / World J Gastroenterol 15 : 3073 ~ 3085
5. [학술지(정기간행물)] - Hasegawa H / 2004 / Proof of the mysterious effi cacy of ginseng: basic and clinical trials: metabolic activation of ginsenoside: deglycosylation by intestinal bacteria and esterifi - cation with fatty acid / J Pharmacol Sci 95 : 153 ~ 157
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UCI(KEPA) : I410-ECN-0101-2012-524-004215865