지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.3
- 수록면
- 80 - 85 (6page)
이용수
초록· 키워드
오류제보하기
Ginseng, a traditional medicine in Asian countries, is known to prevent various neuropathologic diseases such as Alzheimer’s. Ginseng total saponins (GTS) in particular are one of the most effective ginseng extract compounds for neuroprotection. However, their protective effects on astrocytes are rarely reported. In pathological circumstances, astroglial activation plays a pivotal role in neuroinfl ammation. Subsequently, neuroinfl ammation induced by activated astrocytes causes brain damage. The purpose of the present study was to determine the suppressive effects of GTS on astroglial activation in lipopolysaccharide (LPS)- stimulated rat primary astrocytes. Astrocytes treated for 24 h with LPS demonstrated suppressed glial fi brillary acidic protein expression in a dose-dependent manner in the presence of GTS. GTS reduced production of proinfl ammatory cytokines such as tumor necrosis factor-α and interleukin-1β and inhibited the level of inducible nitric oxide synthase, and cyclooxygenase-2 in LPS-stimulated astrocytes. Furthermore, GTS suppressed intracellular reactive oxygen species production. These modulations due to GTS may indicate neuroprotective antiinfl ammatory properties which may in turn be related to improvements in neurological performance.
목차
INTRODUTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
ACKNOWLEDGEMENTS
REFERENCES
참고문헌 (26)
참고문헌 신청
1. [학술지(정기간행물)] - Markiewicz I / 2006 / The role of astrocytes in the physiology and pathology of the central nervous system / Acta Neurobiol Exp 66 : 343 ~ 358
2. [학술지(정기간행물)] - Cerciat M / 2010 / Selective estrogen receptor modulators decrease the production of interleukin-6 and interferon-gamma-inducible protein-10 by astrocytes exposed to inflammatory challenge in vitro / Glia 58 : 93 ~ 102
3. [학술지(정기간행물)] - Ridet JL / 1997 / Reactive astrocytes: cellular and molecular cues to biological function / Trends Neurosci 20 : 570 ~ 577
4. [학술지(정기간행물)] - Liu MH / 2009 / Anti-infl ammatory effects of daidzein on primary astroglial cell culture / Nutr Neurosci 12 : 123 ~ 134
5. [단행본] - Tang W / 1992 / Chinese drugs of plant origin: chemistry, pharmacology, and use in traditional and modern medicine / Springer-Verlag
2. [학술지(정기간행물)] - Cerciat M / 2010 / Selective estrogen receptor modulators decrease the production of interleukin-6 and interferon-gamma-inducible protein-10 by astrocytes exposed to inflammatory challenge in vitro / Glia 58 : 93 ~ 102
3. [학술지(정기간행물)] - Ridet JL / 1997 / Reactive astrocytes: cellular and molecular cues to biological function / Trends Neurosci 20 : 570 ~ 577
4. [학술지(정기간행물)] - Liu MH / 2009 / Anti-infl ammatory effects of daidzein on primary astroglial cell culture / Nutr Neurosci 12 : 123 ~ 134
5. [단행본] - Tang W / 1992 / Chinese drugs of plant origin: chemistry, pharmacology, and use in traditional and modern medicine / Springer-Verlag
이 논문의 저자 정보
이 논문과 함께 이용한 논문
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2012-524-004215850