지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.3
- 수록면
- 69 - 79 (11page)
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초록· 키워드
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Hepatocellular carcinoma (HCC) is the fi fth most common malignancy in the world and complicates liver cirrhosis related to hepatitis C virus (HCV) in many cases. We evaluated the therapeutic effect of Korean red ginseng extract (KGE) in patients with chronic liver diseases. Thirty male and female patients with HCC and another thirty with liver cirrhosis were included. Each category was divided into two groups; the fi rst was used as control group, and received medical therapy only and the second group received the medical therapy supplemented with KGE capsules. The treated group with HCC received three KGE capsules/day (900 ㎎) while the treated group with HCV received two KGE capsules/day (600 ㎎) for 11 weeks along with their medical therapy. All patients were subjected to clinical examination and laboratory investigations, including liver function tests (at baseline, after 6 weeks of treatment and at the end of the study) and abdominal ultrasonography. Patients showing focal hepatic lesions were subjected to triphasic spiral abdominal computerized tomography and alpha-fetoprotein (AFP). HCV RNA was determined quantitatively by Roche for patients in the HCV group. Results showed that the medical therapy alone failed to normalize the liver enzymes or decrease the virus concentration. KGE administration induced a signifi cant improvement in liver function tests, decreased the tumor marker (AFP) levels, and decreased the viral titers in HCV patients. Thus, KGE demonstrated powerful therapeutic effects against HCV and liver cancer.
목차
INTRODUCTION
RESULTS
DISCUSSION
ACKNOWLEDGMENTS
REFERENCES
참고문헌 (75)
참고문헌 신청
1. [학술지(정기간행물)] - El-Serag HB / 2007 / Hepatocellular carcinoma: epidemiology and molecular carcinogenesis / Gastroenterology 132 : 2557 ~ 2576
2. [학술지(정기간행물)] - Velazquez RF / 2003 / Prospective analysis of risk factors for hepatocellular carcinoma in patients with liver cirrhosis / Hepatology 37 : 520 ~ 527
3. [학술지(정기간행물)] - Rahman El-Zayadi A / 2001 / Prevalence and epidemiological features of hepatocellular carcinoma in Egypt: a single center experience / Hepatol Res 19 : 170 ~ 179
4. [학술지(정기간행물)] - Farazi PA / 2006 / Hepatocellular carcinoma pathogenesis: from genes to environment / Nat Rev Cancer 6 : 674 ~ 687
5. [단행본] - Soldati F / 2000 / Panax ginseng: standardization and biological activity, in Biologically active natural products: pharmaceuticals / CRC Press : 209 ~ 232
2. [학술지(정기간행물)] - Velazquez RF / 2003 / Prospective analysis of risk factors for hepatocellular carcinoma in patients with liver cirrhosis / Hepatology 37 : 520 ~ 527
3. [학술지(정기간행물)] - Rahman El-Zayadi A / 2001 / Prevalence and epidemiological features of hepatocellular carcinoma in Egypt: a single center experience / Hepatol Res 19 : 170 ~ 179
4. [학술지(정기간행물)] - Farazi PA / 2006 / Hepatocellular carcinoma pathogenesis: from genes to environment / Nat Rev Cancer 6 : 674 ~ 687
5. [단행본] - Soldati F / 2000 / Panax ginseng: standardization and biological activity, in Biologically active natural products: pharmaceuticals / CRC Press : 209 ~ 232
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UCI(KEPA) : I410-ECN-0101-2012-524-004215845