지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.3
- 수록면
- 39 - 44 (6page)
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초록· 키워드
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We studied the acute oral toxicity of black ginseng (BG) produced by heat process in rats. Single acute BG extract doses of 0, 5, 10, and 15 g/㎏ dissolved in saline were administered by oral gavage and the animals were kept under observation for 14 days. The single administration of BG extract up to 15 g/㎏ did not produce mortality, behavioral change or abnormal clinical signs in the rats. These results indicated that the oral LD?? of the BG extract in the rats is higher than 15 g/㎏. Compared to the control group, no treatment-related biologically signifi cant effects of BG extract were noted in the measurements of the body weight or food intake. At the end of the period, the biochemical parameters and hematological parameters were analyzed in the plasma and blood. A histopathological examination of the liver and kidney was also conducted. Only the blood nitrogen urea and potassium levels in the biochemical indices showed signifi cant differences at 10 and 15 g/㎏ doses of BG extract compared to the control group. These changes were not considered to be due to the toxicity. None of the other clinical chemistry parameters were affected. Therefore, these results indicate that the BG by heat processing is virtually nontoxic.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
ACKNOWLEDGEMENTS
REFERENCES
참고문헌 (16)
참고문헌 신청
1. [학술지(정기간행물)] - Gillis CN / 1997 / Panax ginseng pharmacology: a nitric oxide link / Biochem Pharmacol 54 : 1 ~ 8
2. [학술지(정기간행물)] - Attele AS / 1999 / Ginseng pharmacology: multiple constituents and multiple actions / Biochem Pharmacol 58 : 1685 ~ 1693
3. [학술지(정기간행물)] - Kim WY / 2000 / Steaming of ginseng at high temperature enhances biological activity / J Nat Prod 63 : 1702 ~ 1704
4. [학술지(정기간행물)] - Han BH / 1982 / Degradation of ginseng saponins under mild acidic conditions / Planta Med 44 : 146 ~ 149
5. [학술지(정기간행물)] - Cheng LQ / 2008 / Conversion of major ginsenoside Rb1 to 20(S)-ginsenoside Rg3 by Microbacterium sp. GS514 / Phytochemistry 69 : 218 ~ 224
2. [학술지(정기간행물)] - Attele AS / 1999 / Ginseng pharmacology: multiple constituents and multiple actions / Biochem Pharmacol 58 : 1685 ~ 1693
3. [학술지(정기간행물)] - Kim WY / 2000 / Steaming of ginseng at high temperature enhances biological activity / J Nat Prod 63 : 1702 ~ 1704
4. [학술지(정기간행물)] - Han BH / 1982 / Degradation of ginseng saponins under mild acidic conditions / Planta Med 44 : 146 ~ 149
5. [학술지(정기간행물)] - Cheng LQ / 2008 / Conversion of major ginsenoside Rb1 to 20(S)-ginsenoside Rg3 by Microbacterium sp. GS514 / Phytochemistry 69 : 218 ~ 224
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UCI(KEPA) : I410-ECN-0101-2012-524-004215805