지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.3
- 수록면
- 47 - 52 (6page)
이용수
초록· 키워드
오류제보하기
Antiulcer effects of pantoprazole, a proton-pump inhibitor, on water-immersion restraint stress (WIRS)-, alcohol (ethanol)- and pylorus ligation-induced gastric ulcers were investigated in male rats. Rats were orally administered with pantoprazole 30 min prior to exposure to various types of ulcer inducers. In stress-induced ulcer model, rats were subjected to WIRS at 22℃ for 4 hours, and the degree of ulcer (in ㎜) was evaluated. In alcohol-induced ulcer model, rats were orally administered with pure (100%) ethanol (1 ㎖/㎏), and the ulcer lesions were measured 1 hour after ethanol challenge. In pylorus ligationinduced ulcer model, rats were subjected to pylorus ligation, and the degree of erosions and ulcers was scored 17 hours after the operation. Pantoprazole attenuated the ulcer lesions induced by WIRS in a dose-dependent manner, exhibiting a median effective dose (ED??) value of 0.78 ㎎/㎏. By comparison, pantoprazole was effective at relatively-high doses for the improvement of ethanol-induced ulcers, showing an ED?? value of 20.5 ㎎/㎏. Notably, pantoprazole was practically ineffective (ED??>50.0) in pylorus ligation model. Taken together, it was confirmed that pantoprazole showed inhibitory activity on gastric ulcers induced by stress and alcohol, but was ineffective on pylorus ligation-induced ulcer. Therefore, the results indicate that proton-pump inhibitors including pantoprazole might reveal highlydifferent effects according to the type of ulcer inducers, and that the prescription of antiulcer agents should be carefully selected.
목차
Materials and Methods
Results and Discussion
Acknowledgments
References
참고문헌 (33)
참고문헌 신청
Byun SK / 2007 / The Role of Corticosteroids in Stress-Induced Gastric Ulceration in Rats / Laboratory Animal Research 23(2):127~131
Cantarella G / 2005 / Adrenomedullin modulates COX-2 and HGF expression in reserpine-injured gastric mucosa in the rat / Eur J Pharmacol 518:221~226
Cantarella G / 2007 / Protective effects of amylin on reserpine-injured gastric damage in the rat / Pharmacol Res 56:27~34
Cao H / 2004 / Comparison of the effects of pantoprazole enantimers on gastric mucosal lesions and gastric epithelial cells in rats / J Health Sci 50:1~8
Cao H / 2005 / Pharmacodynamic comparison of pantoprazole enantimers: inhibition of acid-related lesions and acid secretion in rats and guinea-pigs / J Pharm Pharmacol 57:923~927
Cantarella G / 2005 / Adrenomedullin modulates COX-2 and HGF expression in reserpine-injured gastric mucosa in the rat / Eur J Pharmacol 518:221~226
Cantarella G / 2007 / Protective effects of amylin on reserpine-injured gastric damage in the rat / Pharmacol Res 56:27~34
Cao H / 2004 / Comparison of the effects of pantoprazole enantimers on gastric mucosal lesions and gastric epithelial cells in rats / J Health Sci 50:1~8
Cao H / 2005 / Pharmacodynamic comparison of pantoprazole enantimers: inhibition of acid-related lesions and acid secretion in rats and guinea-pigs / J Pharm Pharmacol 57:923~927
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UCI(KEPA) : I410-ECN-0101-2012-510-004225521