지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.3
- 수록면
- 41 - 46 (6page)
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초록· 키워드
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The faded mouse is a coat color mutant that shows faded coat color and age-related loss of pigmentation. This mutation is transmitted by an autosomal recessive gene with 100% penetrance. In the present study, we carried out linkage analysis of the faded (fe) gene using intra-specific backcross panels. Affected faded mice were carefully confirmed by their faded coat color at about 4 weeks of age. In the intra-specific backcross between faded and CBA mice (n=198), the fe gene was mapped to a region 2.1 cM distal to D10mit191. Therefore, the gene order was defined as follows: centromere-D10mit51 (12.4±2.4 cM)-D10mit191 (2.1±1.0 cM)-fe-D10mit44 (13.3±2.4 cM)-D10mit42 (14.4±2.5 cM). This linkage map of the fe locus will provide a good entry point to isolate the fe gene. Since the faded mouse has pigmentary abnormalities, this mutant may be a useful model for studies of pigmentary abnormalities in humans.
목차
Materials and Methods
Results
Discussion
Acknowledgments
References
참고문헌 (32)
참고문헌 신청
Brilliant MH / 2001 / The mouse p (pink-eyed dilution) and human P genes, oculocutaneous albinism type 2 (OCA2), and melanosomal pH / Pigment Cell Res 14(2):86~93
Cable J / 1993 / Light (Blt), a mutation that causes melanocyte death, affects stria vascularis function in the mouse inner ear / Pigment Cell Res 6:215~225
Edery P / 1996 / Mutation of the endothelin- 3 gene in the Waardenburg-Hirschsprung disease (Shah- Waardenburg syndrome) / Nat Genet 12(4):442~444
Fukuta K / 1991 / Pink-eyed dilution, a coat color mutation in the Japanese field vole (Microtus montebelli) / Jikken Dobutsu 40(3):375~379
Green EL / 1981 / Linkage, recombination and mapping. In: Genetics and probability in animal breeding experiments / Oxford University Press :77~133
Cable J / 1993 / Light (Blt), a mutation that causes melanocyte death, affects stria vascularis function in the mouse inner ear / Pigment Cell Res 6:215~225
Edery P / 1996 / Mutation of the endothelin- 3 gene in the Waardenburg-Hirschsprung disease (Shah- Waardenburg syndrome) / Nat Genet 12(4):442~444
Fukuta K / 1991 / Pink-eyed dilution, a coat color mutation in the Japanese field vole (Microtus montebelli) / Jikken Dobutsu 40(3):375~379
Green EL / 1981 / Linkage, recombination and mapping. In: Genetics and probability in animal breeding experiments / Oxford University Press :77~133
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UCI(KEPA) : I410-ECN-0101-2012-510-004225516