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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.3
- 수록면
- 25 - 28 (4page)
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초록· 키워드
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Renal toxicity by melamine in combination with cyanuric acid (1:1) was investigated. Male rats were orally administered melamine plus cyanuric acid (5, 50 or 400 ㎎/㎏ each) for 3 days. In contrast to a negligible effect by melamine alone (50 ㎎/㎏, a no-observed-adverse-effect-level: NOAEL), coadministration with cyanuric acid markedly increased the concentrations of blood urea nitrogen and creatinine, as well as kidney weight. A high dose (400 ㎎/㎏) of melamine plus cyanuric acid induced more severe kidney toxicity. The increased blood parameters for kidney toxicity and organ weight lasted longer than 4 days. Combined treatment with melamine and cyanuric acid (50?400 ㎎/㎏ each) resulted in many gold-brown crystals and toxic lesions in renal tubules, which were not observed in animals treated with melamine alone (50 mg/kg). These results indicate that only a 3-day exposure to melamine in combination with cyanuric acid causes severe renal damage, even at a NOAEL for melamine found in a 13-week toxicity study. Therefore, it is suggested that the tolerable daily intake or regulatory/management levels of melamine need to be re-considered for cases of co-exposure with cyanuric acid.
목차
Materials and Methods
Results
Discussion
Acknowledgment
References
참고문헌 (13)
참고문헌 신청
Ames MM / 1979 / Disposition and metabolism of pentamethylmelamine and hexamethylmelamine in rabbits and humans / Cancer Res 39:5016~5021
Brown CA / 2007 / Outbreaks of renal failure associated with melamine and cyanuric acid in dogs and cats in 2004 and 2007 / J Vet Diagn Invest 19:525~531
Cook AM / 1985 / Ring cleavage and degradative pathway of cyanuric acid in bacteria / Biochem J 231:25~30
Dobson RLM / 2008 / Identification and characterization of toxicity of contaminants in pet food leading to an outbreak of renal toxicity in cats and dogs / Toxicol Sci 106:251~262
Hammond BG / 1986 / A review of toxicology studies on cyanurate and its chlorinated derivatives / Environ Health Perspect 69:287~292
Brown CA / 2007 / Outbreaks of renal failure associated with melamine and cyanuric acid in dogs and cats in 2004 and 2007 / J Vet Diagn Invest 19:525~531
Cook AM / 1985 / Ring cleavage and degradative pathway of cyanuric acid in bacteria / Biochem J 231:25~30
Dobson RLM / 2008 / Identification and characterization of toxicity of contaminants in pet food leading to an outbreak of renal toxicity in cats and dogs / Toxicol Sci 106:251~262
Hammond BG / 1986 / A review of toxicology studies on cyanurate and its chlorinated derivatives / Environ Health Perspect 69:287~292
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UCI(KEPA) : I410-ECN-0101-2012-510-004225485