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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.3
- 수록면
- 19 - 24 (6page)
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초록· 키워드
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The hexane extract of Rheum undulatum L. (HERL) has been shown to have anti-cancer activity in several cancers in vivo and in vitro. However, the anti-cancer activity of HERL and its molecular mechanism in human oral cancer cells has not been explored. Thus, the aim of this study was to elucidate the growthinhibitory and apoptosis-inducing effects of HERL in HN22 and SCC15 oral cancer cell lines. This study shows that HERL inhibits oral cancer growth, decreases cell viability, and causes apoptotic cell death in HN22 and SCC15 cells, as characterized by morphological changes, nuclear condensation and fragmentation, the cleavage of PARP and the accumulation of cells in the sub-G1 phase. The treatment of oral cancer cells with HERL also resulted in decreased expression of specificity protein (Sp1) and its downstream protein, survivin. Therefore, our results suggest that the regulation of Sp1 and survivin plays a critical role in HERL-induced apoptosis in human oral cancer cells.
목차
Materials and Methods
Results
Discussion
References
참고문헌 (31)
참고문헌 신청
1. [학술지(정기간행물)] - Abdelrahim M / 2006 / Tolfenamic acid and pancreatic cancer growth, angiogenesis, and Sp protein degradation / J Natl Cancer Inst 98 : 855 ~ 868
2. [학술지(정기간행물)] - Cha TL / 2005 / Emodin downregulates androgen receptor and inhibits prostate cancer cell growth / Cancer Res 65 : 2287 ~ 2295
3. [학술지(정기간행물)] - Chang CH / 1996 / Antiinflammatory effects of emodin from ventilago leiocarpa / Am J Chin Med 24 : 139 ~ 142
4. [학술지(정기간행물)] - Chiefari E / 2002 / Increased expression of AP2 and Sp1 transcription factors in human thyroid tumors: a role in NIS expression regulation / BMC Cancer 2 : 35 ~
5. [학술지(정기간행물)] - Dorsey JF / 2007 / Aloe(-emodin) for cancer? More than just a comforting salve / Cancer Biol Ther 6 : 89 ~ 90
2. [학술지(정기간행물)] - Cha TL / 2005 / Emodin downregulates androgen receptor and inhibits prostate cancer cell growth / Cancer Res 65 : 2287 ~ 2295
3. [학술지(정기간행물)] - Chang CH / 1996 / Antiinflammatory effects of emodin from ventilago leiocarpa / Am J Chin Med 24 : 139 ~ 142
4. [학술지(정기간행물)] - Chiefari E / 2002 / Increased expression of AP2 and Sp1 transcription factors in human thyroid tumors: a role in NIS expression regulation / BMC Cancer 2 : 35 ~
5. [학술지(정기간행물)] - Dorsey JF / 2007 / Aloe(-emodin) for cancer? More than just a comforting salve / Cancer Biol Ther 6 : 89 ~ 90
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UCI(KEPA) : I410-ECN-0101-2012-510-004225470