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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Skin is the most superficial body organ and plays an important role in protecting the body from environmental damage and in forming social relations. With the increase of the aging population in our society, dermatological and cosmetic concerns of skin aging are rapidly increasing. Skin aging is a complex process combined with intrinsic and extrinsic factors. Intrinsic or chronological skin aging results from the passage of time and is influenced by genetic factors. Extrinsic skin aging is mainly determined by UV irradiation, also called photoaging. These two types of aging processes are superimposed on sunexposed skin, and have a common feature of causing dermal matrix alterations that mostly contribute to the formation of wrinkles, laxity, and fragility of aged skin. The dermal matrix contains extracellular matrix proteins such as collagen, elastin, and proteoglycans that confer the strength and resiliency of skin. Skin aging associated with dermal matrix alterations and atrophy can be caused by cellular senescence of dermal cells like fibroblasts, and decreased synthesis and accelerated degradation of dermal matrix components, especially collagen fibers. Both intrinsic aging and photoaging exert influence during each step of dermal matrix alteration via different mechanisms. Mouse models of skin aging have been extensively developed to elucidate intrinsic aging and photoaging processes, to validate in vitro biochemical data, and to test the effects of pharmacological tools for retarding skin aging because they have the advantages of being genetically similar to humans and are easily available.
목차
Characteristics of Skin Aging
Dermal Connective Tissue
Molecular Mechanisms of Skin Aging
Summary
Acknowledgments
References
참고문헌 (78)
참고문헌 신청
Allsopp RC / 1992 / Telomere length predicts replicative capacity of human fibroblasts / Proc Natl Acad Sci USA 89(21):10114~10118
Bateman A / 1996 / Fibronectin type III domains in yeast detected by a hidden Markov model / Curr Biol 6(12):1544~1547
Baumann L / 2007 / Skin ageing and its treatment / J Pathol 211(2):241~251
Bhattacharyya TK / 2004 / Histomorphologic changes in aging skin: observations in the CBA mouse model / Arch Facial Plast Surg 6(1):21~25
Bitzer M / 2000 / Dominguez-Rosales A, Beg AA, Rojkind M, Bottinger EP. A mechanism of suppression of TGF-beta/SMAD signaling by NF-kappa B/RelA / Genes Dev 14(2):187~197
Bateman A / 1996 / Fibronectin type III domains in yeast detected by a hidden Markov model / Curr Biol 6(12):1544~1547
Baumann L / 2007 / Skin ageing and its treatment / J Pathol 211(2):241~251
Bhattacharyya TK / 2004 / Histomorphologic changes in aging skin: observations in the CBA mouse model / Arch Facial Plast Surg 6(1):21~25
Bitzer M / 2000 / Dominguez-Rosales A, Beg AA, Rojkind M, Bottinger EP. A mechanism of suppression of TGF-beta/SMAD signaling by NF-kappa B/RelA / Genes Dev 14(2):187~197
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UCI(KEPA) : I410-ECN-0101-2012-510-004225450