지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국식품영양과학회 Journal of Food Science and Nutrition Journal of Food Science and Nutrition Vol.16 No.1
- 발행연도
- 2011.3
- 수록면
- 18 - 23 (6page)
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초록· 키워드
오류제보하기
Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by neuronal loss and extracellular senile plaques containing β-amyloid peptide (Aβ). The deposition of the Aβ peptide following proteolytic processing of amyloid precursor protein (APP) by β-secretase (BACE1) and γ-secretase is a critical feature in the progression of AD. Among the plant extracts tested, the ethanol extract of Petasites japonicus leaves showed novel protective effect on B103 neuroblastoma cells against neurotoxicity induced by Aβ, as well as a strong suppressive effect on BACE1 activity. Ethanol extracts of P. japonicus leaves were sequentially extracted with methylene chloride, ethyl acetate and butanol and evaluated for potential to inhibit BACE1, as well as to suppress Aβ-induced neurotoxicity. Exposure to Aβ significantly reduced cell viability and increased apoptotic cell death. However, pretreatment with ethyl acetate fraction of P. japonicus leaves prior to Aβ (50 μM) significantly increased cell viability (p＜0.01). In parallel, cell apoptosis triggered by Aβ was also dramatically inhibited by ethyl acetate fraction of P. japonicus leaves. Moreover, the ethyl acetate fraction suppressed caspase-3 activity to the basal level at 30 ppm. Taken together, these results demonstrated that P. japonicus leaves appear to be a useful source for the inhibition and/or prevention of AD by suppression of BACE1 activity and attenuation of Aβ induced neurocytotoxicity.
목차
Abstract
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
ACKNOWLEDGEMENTS
REFERENCES
참고문헌 (25)
참고문헌 신청
1. [학술지(정기간행물)] - Glenner GG / 1984 / Alzheimer’s disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein / Biochem Biophys Res Commun 120 : 885 ~ 890
2. [학술지(정기간행물)] - Citron M / 2004 / Strategies for disease modification in Alzheimer’s disease / Nat Rev Neurosci 5 : 677 ~ 685
3. [학술지(정기간행물)] - Selkoe DJ / 1994 / Normal and abnormal biology of the β-amyloid precursor protein / Annu Rev Neurosci 17 : 489 ~ 517
4. [학술지(정기간행물)] - Miranda S / 2000 / The role of oxidative stress in the toxicity induced by amyloid beta-peptide in Alzheimer’s disease / Prog Neurobiol 62 : 633 ~ 648
5. [학술지(정기간행물)] - Behl C / 1994 / Hydrogen peroxide mediates amyloid-beta protein toxicity / Cell 77 : 817 ~ 827
2. [학술지(정기간행물)] - Citron M / 2004 / Strategies for disease modification in Alzheimer’s disease / Nat Rev Neurosci 5 : 677 ~ 685
3. [학술지(정기간행물)] - Selkoe DJ / 1994 / Normal and abnormal biology of the β-amyloid precursor protein / Annu Rev Neurosci 17 : 489 ~ 517
4. [학술지(정기간행물)] - Miranda S / 2000 / The role of oxidative stress in the toxicity induced by amyloid beta-peptide in Alzheimer’s disease / Prog Neurobiol 62 : 633 ~ 648
5. [학술지(정기간행물)] - Behl C / 1994 / Hydrogen peroxide mediates amyloid-beta protein toxicity / Cell 77 : 817 ~ 827
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UCI(KEPA) : I410-ECN-0101-2012-511-004225819