지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.3
- 수록면
- 49 - 52 (4page)
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초록· 키워드
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The aim of this study is to investigate how many leiomyoma patients are exposed to bisphenol-A (BPA), an endocrine disruptor, and whether the serum concentration of BPA is related to leiomyoma growth. Initially, 128 patients were divided into one control and three leiomyoma groups (mild, moderate and severe) according to the size of the leiomyomas. Serum BPA concentrations were measured by liquid chromatography and mass spectrometry (LC/MS). Nearly two-thirds of leiomyoma patients were exposed to BPA and the range of BPA was from non-detection to 2.603 ng/㎖. The mean BPA concentrations in the groups were 1.015 ± 0.775 ng/㎖ (control), 0.774 ± 0.834 ng/㎖ (mild), 1.261 ± 0.797 ng/㎖ (moderate) and 1.244 ± 0.860 ng/㎖ (severe) (p = 0.158). After recombination into two group, Group 1 (control plus mild) vs. Group 2 (moderate plus severe), higher level was found in Group 2 even with no statistical significance (p = 0.06). In conclusion, about two-thirds of leiomyoma patients were exposed to BPA, but it may not have growth promoting effect on leiomyoma.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
Discussion
ACKNOWLEDGMENTS
REFERENCES
참고문헌 (15)
참고문헌 신청
Buttram, V.J / 1981 / Uterine leiomyomata: Etiology,symptomatology, and management / Fertil. Steril 36:433~445
Calafat, A.M / 2008 / Exposure of U.S. population to bisphenol-A and 4-tertiary-octyl phenol: 2003-2004 / Environ. Health Perspect 116:39~44
Gould, J.C. / 1998 / Bisphenol A interacts with estrogen receptor alpha in adistinct manner from estradiol / Mol. Cell. Endocrinol 142:203~214
Hodges, L.C. / 2001 / An in vivo/in vitro model to assess endocrinedisrupting activity of xenoestrogens in uterine leiomyoma / Ann. N. Y. Acad. Sci 948:100~111
Inoue, K. / 2000 / Determination of bisphenol A in human serum by highperformanceliquid chromatography with multi-electrode electrochemicaldetection / J. Chromatogr. B 749:17~23
Calafat, A.M / 2008 / Exposure of U.S. population to bisphenol-A and 4-tertiary-octyl phenol: 2003-2004 / Environ. Health Perspect 116:39~44
Gould, J.C. / 1998 / Bisphenol A interacts with estrogen receptor alpha in adistinct manner from estradiol / Mol. Cell. Endocrinol 142:203~214
Hodges, L.C. / 2001 / An in vivo/in vitro model to assess endocrinedisrupting activity of xenoestrogens in uterine leiomyoma / Ann. N. Y. Acad. Sci 948:100~111
Inoue, K. / 2000 / Determination of bisphenol A in human serum by highperformanceliquid chromatography with multi-electrode electrochemicaldetection / J. Chromatogr. B 749:17~23
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UCI(KEPA) : I410-ECN-0101-2012-513-004366342