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논문 기본 정보

자료유형
학술저널
저자정보
Yoon-Kyung Jo (동남보건대학) Ju-Won Seok (중앙대학교병원) Jung-Ha Kim (중앙대학교병원)
저널정보
대한의생명과학회 대한의생명과학회지 대한의생명과학회지 제16권 제4호
발행연도
2010.12
수록면
293 - 298 (6page)

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Several risk factors for osteoporosis are known relatively well. Some nutrients are directly or indirectly needed for metabolic processes related to bone. Recently, an increased prevalence of osteoporosis has been reported in patients with hemochromatosis, an iron overload disease. Thus, the aim of this study was to find out if there was any relationship between serum ferritin and T-score of bone mineral density in healthy women. We recruited 1,101 subjects females aged between 39 and 85 years. We measured serum ferritin, glucose tolerance indices, lipid profiles, inflammatory indices, hormones, calcium, alkaline phosphatase. Also, anthropometric, blood pressure, and bone mineral density measurements were performed. T-score was negatively correlated with age (r=-0.425; P<0.01), systolic (r=-0.109; P<0.01) and diastolic (r=-0.093; P<0.01) pressure, follicular stimulation hormone (r=-0.190; P<0.01), alkaline phosphatase (r=-0.235; P<0.01), and serum ferritin (r=-0.090; P<0.05) and positively with body mass index (r=0.050; P=0.01), HDL-cholesterol (r=0.314; P<0.01), and estradiol (r=0.200; P<0.01). After adjustment for age, alkaline phosphatase, body mass index, HDL-cholesterol, estradiol, and follicular stimulation hormone, serum ferritin was independently inversely correlated with T-score (β=-0.001; P<0.05). It is possible that an increase of serum ferritin in females may be risk to osteoporosis.

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UCI(KEPA) : I410-ECN-0101-2012-510-004137286