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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.12
- 수록면
- 259 - 264 (6page)
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This study was designed to investigate the effects of nitric oxide on the neuronal activity of rat cerebellar Purkinje cells. Sprague-Dawley rats aged 14 to 16 days were decapitated under ether anesthesia. After treatment with pronase and thermolysin, the dissociated Purkinje cells were transferred into a chamber on an inverted microscope. Spontaneous action potentials and potassium currents were recorded by standard patch-clamp techniques under current and voltageclamp modes respectively. 15 Purkinje cells revealed excitatory responses to 20 μM of sodium nitroprusside (SNP) and 4 neurons (20%) did not respond to SNP. Whole potassium currents of Purkinje cells were decreased by SNP (n=10). Whole potassium currents of Purkinje cells were also decreased by L-arginine, substrate of nitric oxide (n=10). These experimental results suggest that nitric oxide increases the neuronal activity of Purkinje cells by altering the resting membrane potential and afterhyperpolarization.
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감사의 글
REFERENCES
참고문헌 (27)
참고문헌 신청
Aoki M / 1996 / Evidence for the involvement of NMDA receptors in vestibular compensation / J Vet Res 6:315~317
Bon C / 1994 / A role for nitric oxide in long term potentiation / Eur J Neurosci 4:420~424
Bredt DS / 1990 / Localization of nitric oxide synthase, indicating a neuronal role for nitric oxide / Nature 347:768~770
Bredt DS / 1992 / Nitric oxide, a novel neuronal messenger / Neuron 8:3~11
Brune B / 1989 / Activation of a cytosolic ADP-ribosyl transferase by nitric oxide-gnerating agents / J Biol Chem 264:8455~8458
Bon C / 1994 / A role for nitric oxide in long term potentiation / Eur J Neurosci 4:420~424
Bredt DS / 1990 / Localization of nitric oxide synthase, indicating a neuronal role for nitric oxide / Nature 347:768~770
Bredt DS / 1992 / Nitric oxide, a novel neuronal messenger / Neuron 8:3~11
Brune B / 1989 / Activation of a cytosolic ADP-ribosyl transferase by nitric oxide-gnerating agents / J Biol Chem 264:8455~8458
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논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
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[지상3]Phosphorylated Tyrosine Hydroxylase Expression in the Purkinje Cells of the Pogo Mouse
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INCREASED NITRIC OXIDE PRODUCTION MEDIATES ISCHEMIC BRAIN DAMAGE : DIRECT MEASUREMENT OF NITRIC OXIDE AND ENHANCED ACTIVITY OF NITRIC OXIDE SYNTHASE IN BRAIN MICROVESSELS AFTER CEREBRAL ISCHEMIA
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Immunohistochemical study on the distribution of the Hsp25-immunoreactive Purkinje cells in Gerbil and Mouse Cerebellum
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Nitric Oxide 가 담낭의 운동성에 미치는 영향
Annals of Hepato-Biliary-Pancreatic Surgery
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Abnormal Expression of Tyrosine Hydroxylase in the Cerebellar Purkinje cells of the Ataxic Mutant Mouse, pogo
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Therapeutic Application of Nitric Oxide in Human Diseases
Biomolecules & Therapeutics(구 응용약물학회지)
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Neuroprotective Mechanism of Bone Marrow derived-mesenchymal Stem Cells to Survive Purkinje Neurons in Niemann-Pick Type C Mice
한국실험동물학회 학술발표대회 논문집
2009 .04
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NITRIC OXIDE와 치수
Restorative Dentistry and Endodontics
2002 .01
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Inhibition of Nitric Oxide Production from lipopolysaccharide-Treated RAW 264.7 Cells by Synthetic Flavones：Structure-Activity Relationship and Action Mechanism
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2004 .01
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UCI(KEPA) : I410-ECN-0101-2012-510-004137231