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논문 기본 정보

자료유형
학술저널
저자정보
Jong Seong Lee (직업성폐질환연구소) Jae Hoon Shin (직업성폐질환연구소) Joung Oh Lee (직업성폐질환연구소) Kyung Myung Lee (직업성폐질환연구소) Ji Hong Kim (근로복지공단) Byung-Soon Choi (직업성폐질환연구소)
저널정보
한국독성학회 Toxicological Research Toxicological Research Vol.26 No.4
발행연도
2010.12
수록면
329 - 337 (9page)

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초록· 키워드

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Inhaled inorganic dusts, such as coal, can cause inflammation and fibrosis in the lungs, known as pneumoconiosis. Diagnosis of pneumoconiosis depends on morphological changes by radiological findings and functional change by pulmonary function test (PFT). Unfortunately, current diagnostic findings are limited only to lung fibrosis, which is usually irreversibly progressive. Therefore, it is important that research on potential and prospective biomarkers for pneumoconiosis should be conducted prior to initiation of irreversible radiological or functional changes in the lungs. Analytical techniques using exhaled breath condensate (EBC) or exhaled gas are non-invasive methods for detection of various respiratory diseases. The objective of this study is to investigate the relationship between inflammatory biomarkers, such as EBC pH or fractional exhaled nitric oxide (FE<SUB>NO</SUB>), and pneumoconiosis among 120 retired coal miners (41 controls and 79 pneumoconiosis patients). Levels of EBC pH and FE<SUB>NO</SUB> did not show a statistically significant difference between the pneumoconiosis patient group and pneumoconiosis patients with small opacity classified by International Labor Organization (ILO) classification. The mean concentration of FE<SUB>NO</SUB> in the low percentage FEV₁ (< 80%) was lower than that in the high percentage (80% ≤) (p = 0.023). The mean concentration of FE<SUB>NO</SUB> in current smokers was lower than that in non smokers (never or past smokers) (p = 0.027). Although there was no statistical significance, the levels of FE<SUB>NO</SUB> in smokers tended to decrease, compared with non smokers, regardless of pneumoconiosis. In conclusion, there was no significant relationship between the level of EBC pH or FE<SUB>NO</SUB> and radiological findings or PFT. The effects between exhaled biomarkers and pneumoconiosis progression, such as decreasing PFT and exacerbation of radiological findings, should be monitored.

목차

INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
ACKNOWLEDGEMENTS
REFERENCES

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