지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2010.11
- 수록면
- 4,088 - 4,091 (4page)
이용수
초록· 키워드
오류제보하기
Angiogenesis and vascular fusion is a complex cellular process which has an essential role in tumor growth, tumor metastasis and other pathological processes. Various in vivo and in vitro models have been developed for studying angiogenesis and anastomosis. In vivo models, the observation of angiogenesis is technically difficult and observed effects are also difficult to quantify. For this reason, the compound screening for angiogenesis on in vivo models was limited and the development of angiogenesis research was restrained. Recently, several in vitro models have been attempted to recreate the complex sequence of events of angiogenesis with varying degrees of success. However, the formation of new blood vessels and blood vessel fusion were not attempted to study in vitro models because it was not proved the appropriate model for angiogenesis and vascular fusion.
In this study, we developed a novel microfluidic platform using the appropriate micro-architecture and 3D gel for mimicking angiogenesis. This device demonstrates its capability to precise control the cellular environment, the direction of vessel growth and the distribution of new vessels. Microfluidic platform for angiogenesis and vascular fusion will improve the study about specific vascular fusion and will be beneficial to quantitative angiogenesis assay in further research.
In this study, we developed a novel microfluidic platform using the appropriate micro-architecture and 3D gel for mimicking angiogenesis. This device demonstrates its capability to precise control the cellular environment, the direction of vessel growth and the distribution of new vessels. Microfluidic platform for angiogenesis and vascular fusion will improve the study about specific vascular fusion and will be beneficial to quantitative angiogenesis assay in further research.
목차
Abstract
1. Introduction
2. Materials and Methods
3. Results and Discussion
4. Conclusion
References
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UCI(KEPA) : I410-ECN-0101-2012-550-003944349