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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.6
- 수록면
- 59 - 66 (8page)
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초록· 키워드
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Pseudomonas aeruginosa, as an opportunistic pathogen, establishes a chronic infection in the respiratory track of patients suffering from pneumonia and bronchiectasis, including cystic fibrosis. Biofilm formation inside the oversecreted mucus layer lining the patient airway and production of virulence factors, a process controlled by quorum sensing, are considered to be the major virulence determinants in P. aeruginosa pathogenesis. Recently, an abnormally thickened mucus layer was proven to be anaerobic. Given the fact that currently used antibiotics are less effective under anaerobic environments, these new findings lead us to change the way we confront P. aeruginosa infection. This article reviews pathological features of patient airways that become susceptible to P. aeruginosa infection and bacterial adaptation that contributes to the prolonged survival inside the patient airway.
목차
Ⅰ. Pseudomonas aeruginosa
Ⅱ. Abnormal mucus environments in airway diseases
Ⅲ. Anaerobic growth of P. aeruginosa
Ⅳ. P. aeruginosa biofilm and a new emerged concept on the enhanced biofilm formation during anaerobic respiration
Ⅴ. P. aeruginosa quorum sensing and the future direction
Ⅵ. Conclusions
REFERENCES
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UCI(KEPA) : I410-ECN-0101-2012-475-003678960