지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.6
- 수록면
- 203 - 209 (7page)
이용수
초록· 키워드
오류제보하기
Recently, we demonstrated that a large conductance Ca²?-activated K? channel (BK<SUB>Ca</SUB>) in human umbilical cord vein-derived mesenchymal cells (hUC-MSCs). In this study, we studied effects of quercetin, the flavonoid used for the modulator of cell cycle and the treatment of anti-tumor, on BK<SUB>ca</SUB> in hUC-MSCs using single channel and/or whole cell configuration. Single channel conductance was 277.8±36.2 pS in hUC-MSCs and the value is similar to that of typical BK<SUB>Ca</SUB> channel reported in other cells. The single channel current was activated by increasing of intracellular Ca²?. Quercetin (30~100 μM) increased BKCa in whole cell patch configuration whereas EGCG was not affected on the channel. The activation effect of quercetin on BK<SUB>Ca</SUB> channel was also observed in inside-out configuration. The quercetin-induced BKCa was increased a concentration-dependent manner with an IC?? value of 19.9 μM. Taken together, BK<SUB>Ca</SUB> in hUCMSCs can be an important target for the action of quercetin and the channels are partly may contribute to maintaining homeostasis by regulation of K ion flux in hUC-MSCs.
목차
재료 및 방법
결과
고찰
감사의 글
참고문헌
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Riluzole-Induced Activation of BKCa Channels and Inhibition of Voltage-Gated Na+ Channel in Human Umbilical Cord Vein-Derived Mesenchymal Cells
Laboratory Animal Research
2008 .09
-
Blood vessel regeneration using human umbilical cord derived mesenchymal stem cell in immunodeficient mice
한국실험동물학회 학술발표대회 논문집
2011 .02
-
Establishment of High Throughput Screening System Using Human Umbilical Cord-derived Mesenchymal Stem Cells
International Journal of Oral Biology
2012 .01
-
Human umbilical cord blood derived mesenchymal stem cells (hUCB-MSCs) for future regenerative medicine
한국실험동물학회 학술발표대회 논문집
2008 .05
-
Human umbilical cord mesenchymal stem cells as promising source for cell-based immune-related medicine
대한체질인류학회 학술대회 연제 초록
2016 .05
-
Differentiation of Cholinergic Neuron from Human Umbilical Cord Blood Derived Mesenchymal Stem Cells
대한생식의학회 학술대회
2005 .01
-
Can Umbilical Cord Mesenchymal Stem Cells Treatment Be a Hope for Patients with Refractory Crohn’s Disease?
Gut and Liver
2018 .01
-
The Immunomodulatory Properties Decline in Human Umbilical Cord Blood-derived Mesenchymal Stem Cells Aging Via p38 Mediated Alteration of COX-2/PGE2
한국실험동물학회 학술발표대회 논문집
2014 .02
-
In vitro Differentiation of Human Umbilical Cord-derived Stem Cells and Human Amnion-derived Stem Cells into Hepatocyte-like Cells
대한생식의학회 학술대회
2007 .01
-
Umbilical Cord Blood Transplantation
Immune Network
2003 .06
-
Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells Improve Neuropathology and Cognitive Impairment in Alzheimer’s Disease Mouse Model Through Modulation of Neuroinflammatory Condition
한국실험동물학회 학술발표대회 논문집
2009 .08
-
[지상22]Human Umbilical Cord Blood Stem Cells Injection after Transection of spinal cord of rats
대한체질인류학회 학술대회 연제 초록
2004 .05
-
Neurodifferentiation of Mesenchymal Like Stem Cells from Human Amnion and Umbilical Cord in vitro and in vivo
대한생식의학회 학술대회
2005 .01
-
Cardiomyogenic Potential of Human Umbilical Cord Stem Cells
대한생식의학회 학술대회
2007 .01
-
Expression of Neurotrophic Factors in Injured Spinal Cord after Transplantation of human-Umbilical Cord Blood Stem Cells in Rats
한국실험동물학회 학술발표대회 논문집
2012 .02
-
In situ location of Human Wharton’s Jelly-Derived Mesenchymal Stem Cells
한국실험동물학회 학술발표대회 논문집
2013 .02
-
제대혈 내피기원세포 및 간엽줄기세포의 분화에 대한 연구
대한구강악안면외과학회지
2005 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2010-510-003103717