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논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2010.2
- 수록면
- 40 - 45 (6page)
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초록· 키워드
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Aging is a multifactorial phenomenon characterized by a time-dependent decline in physiological function. The process of aging is one of the most complex and intriguing biological phenomenons. Through the years, hundreds (and perhaps more) of hypotheses have been proposed as potential reasons organisms age. One of the most studied and accepted hypotheses for the molecular basis of aging has been the oxidative stress theory of aging, which was first conceptualized by Denham Harman as the free radical theory of aging and has been modified to the Oxidative Stress Theory of Aging.
The basis of this theory is that a chronic state of oxidative stress exists in all cells of aerobic organisms even under normal physiological conditions because of an imbalance between pro-oxidants and antioxidants, suggesting that antioxidants play an important role in protection of aging in mammalian cells.
Several groups have genetically altered various components of the antioxidant defense system in mice to study the Oxidative Stress Theory of Aging. We already generated peroxiredoxin (Prx) Ⅰ and Ⅱ knockout mice to understand the roles of their proteins in vivo and are studying the mice to know whether Prxs are involved in protection of cellular senescence and organism aging. Underlying research results indicate that Prx Ⅰ and Ⅱ play a role in protection of cellular senescence in mice. In this symposium, I would like to introduce the results of transgenic/ knockout mice for antioxidant enzymes.
The basis of this theory is that a chronic state of oxidative stress exists in all cells of aerobic organisms even under normal physiological conditions because of an imbalance between pro-oxidants and antioxidants, suggesting that antioxidants play an important role in protection of aging in mammalian cells.
Several groups have genetically altered various components of the antioxidant defense system in mice to study the Oxidative Stress Theory of Aging. We already generated peroxiredoxin (Prx) Ⅰ and Ⅱ knockout mice to understand the roles of their proteins in vivo and are studying the mice to know whether Prxs are involved in protection of cellular senescence and organism aging. Underlying research results indicate that Prx Ⅰ and Ⅱ play a role in protection of cellular senescence in mice. In this symposium, I would like to introduce the results of transgenic/ knockout mice for antioxidant enzymes.
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Alteration of antioxidant enzymes in response to oxidative stress and antioxidants
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Peroxiredoxin I regulates the component expression of γ-secretase complex causing the Alzheimer’s disease
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Tuberculosis and Respiratory Diseases
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Application of Antioxidant Transgenic Mice
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폐포상피세포, 대식세포를 비롯한 각종 세포주에서 HO에 의한 Peroxiredoxin 동위효소들의 산화에 따른 불활성화와 재생
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Significance of Cellular Senescence in Aging and Cancer
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노년기 한국인의 스트레스
스트레스硏究
2007 .12
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급성 부동 스트레스 후 척수 회색질에서 Peroxiredoxin I 및 III의 발현 변화
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2006 .01
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고산소에 노출된 신생 백서와 성숙 백서에 있어서Peroxiredoxin I과 II의 발현
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Oxidative Stress and Skin Diseases: Possible Role of Physical Activity
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2014 .01
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UCI(KEPA) : I410-ECN-0101-2010-510-002595180