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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.12
- 수록면
- 285 - 293 (9page)
이용수
초록· 키워드
오류제보하기
The correct prediction of human risk after exposure to chemical and physical compounds has long been a major challenge. For this, the lifetime bioassay using rats and mice is routinely used. However, over the years this assay has clearly come to reveal several drawbacks; for example, large numbers of animals are used, and the assays are slow, insensitive and expensive. Therefore, there is an urgent need for alternative, more valid, carcinogenicity assays. One specific approach in finding alternatives is the use of transgenic mice with modifications in genes associated with the development of cancer, thereby increasing their sensitivity to carcinogens. Generally, the transgenic mouse models could reliably predict the carcinogenic potential of compounds, and importantly, the number of false positives was reduced significantly. These marked advantages of transgenic mouse models have resulted in the FDA in the USA and the European CPMP now allowing the use of transgenic mice in regulatory testing of pharmaceutical compounds as an alternative for a second lifetime bioassay, when a two-year bioassay with rats was carried out. Nonetheless, a more extensive evaluation of transgenic mice using newly developed models and more compounds with different modes of action needs to be carried out in the future. These results of this comprehensive study suggest that some of these models might be useful in hazard identification if used in conjunction with information from other sources in a weight of evidence, integrated analysis approach to risk assessment.
목차
외국에서의 발암성 대체시험법 가이드 라인
발암성 대체시험법
고찰
감사의 글
참고문헌
참고문헌 (38)
참고문헌 신청
1. [학술지(정기간행물)] - Attardi, L.D. / 1999 / The role of p53 in tumour suppression: lessons from mouse models / Cell Mol. Life Sci 55 : 48 ~ 63
2. [보고서] - Beems, R.B. / 2001 / 39-week carcinogenicity study with cyclosorin A in XPA-/- mice, wild type and XPA-/-P53+/- double transgenic mice : 2 ~ 100
3. [학술지(정기간행물)] - Bird, R.P. / 1987 / Observation and quantification of aberrant crypts in the murine colon treated with a colon treated with a colon carcinogen; preliminary findings / Cancer Lett 37 : 147 ~ 151
4. [학술지(정기간행물)] - Bos, J.L. / 1989 / Ras oncogenes in human cancer: A review / Cancer Res 49 : 4682 ~ 4689
5. [학술지(정기간행물)] - Bruins, M.R. / 2003 / Characterization of a small plasmid (pMBCP) from bovine Pseudomonas pickettii that confers cadmium resistance / Ecotoxicol. Environ. Saf 54 : 241 ~ 248
2. [보고서] - Beems, R.B. / 2001 / 39-week carcinogenicity study with cyclosorin A in XPA-/- mice, wild type and XPA-/-P53+/- double transgenic mice : 2 ~ 100
3. [학술지(정기간행물)] - Bird, R.P. / 1987 / Observation and quantification of aberrant crypts in the murine colon treated with a colon treated with a colon carcinogen; preliminary findings / Cancer Lett 37 : 147 ~ 151
4. [학술지(정기간행물)] - Bos, J.L. / 1989 / Ras oncogenes in human cancer: A review / Cancer Res 49 : 4682 ~ 4689
5. [학술지(정기간행물)] - Bruins, M.R. / 2003 / Characterization of a small plasmid (pMBCP) from bovine Pseudomonas pickettii that confers cadmium resistance / Ecotoxicol. Environ. Saf 54 : 241 ~ 248
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Comparative gene expression analysis of Alzheimer diseased transgenic mouse
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Overexpression of hARD1235 accelerates Tumorigenesis in APCMIN/+Mice
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Suppression of Transglutaminase-2 is Involved in Anti-Inflammatory Actions of Glucosamine in 12-O-Tetradecanoylphorbol-13-Acetate-Induced Skin Inflammation
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Inflammatory Large Bowel Disease due to Helicobacter hepaticus infection in BALB/cA-Hfh11nu Mice
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Transgenic Knockout Mouse 제작방법의 이해
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Expression of human Interferon α-2a in the milk of transgenic mice
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UCI(KEPA) : I410-ECN-0101-2010-510-001694326