지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.5
- 수록면
- 1,213 - 1,222 (10page)
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초록· 키워드
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Exercise is a commonly used therapeutic procedure in the management for patient of Parkinson's disease; But, neuronal changes with exercise for patients with Parkinson's disease has not been well established, although some clinical and laboratory reports suggest that regular exercise may produce a neuroprotective effect and restore dopaminergic and motor functions. The purpose of this study was to determined the effects of treadmill exercise on the nigrostriatal dopaminergic neurodegeneration in MPTP induced mouse model of Parkinson Disease.
For this study, we used a chronic mouse model(male C57BL/6 mice) of Parkinsonism, which was induced by injecting with 10 doses(Every 12 hour) of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP) 30 ㎎/㎏ and probenecid (20 ㎎/㎏) over 5 days. At the end of exercise training, we examined and compared their locomotor ability(behavior test), neuronal and neurochemical changes with group of control parkinsonian(No-exercise)mice.
The results of this study were summarized as follows:
1) Treadmill training decreased synphilin expression levels in substantia nigra and striatum of MPTP-induced parkinson's disease model.
2) In MPTP-induced parkinson model, treadmill exercise inhibits decrease of cell numbers in substantia nigra and striatum.
3) In MPTP-induced parkinson model with dopamine treatment, treadmill exercise increase p-ERK1/2 expression levels in substantia nigra.
4) The locomotor ability(behavior test) after 4 weeks of exercise in the chronic parkinsonian mice group was significantly higher rate than the pre-exercise, whereas the locomotor ability(behavior test) at the beginning and 4 weeks afterward in the control(No-exercise) parkinsonian mice was unchanged.
The results of this study suggest that treadmill exercise partially prevented dopaminergic neurodegeneration in the nigrostriatal(substantia nigra, striatum, dentate gyrus) region of the Parkinson's Disease model, and this effects were may offer a potential therapeutic adjunct to current Parkinson's Disease therapies in the future.
For this study, we used a chronic mouse model(male C57BL/6 mice) of Parkinsonism, which was induced by injecting with 10 doses(Every 12 hour) of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP) 30 ㎎/㎏ and probenecid (20 ㎎/㎏) over 5 days. At the end of exercise training, we examined and compared their locomotor ability(behavior test), neuronal and neurochemical changes with group of control parkinsonian(No-exercise)mice.
The results of this study were summarized as follows:
1) Treadmill training decreased synphilin expression levels in substantia nigra and striatum of MPTP-induced parkinson's disease model.
2) In MPTP-induced parkinson model, treadmill exercise inhibits decrease of cell numbers in substantia nigra and striatum.
3) In MPTP-induced parkinson model with dopamine treatment, treadmill exercise increase p-ERK1/2 expression levels in substantia nigra.
4) The locomotor ability(behavior test) after 4 weeks of exercise in the chronic parkinsonian mice group was significantly higher rate than the pre-exercise, whereas the locomotor ability(behavior test) at the beginning and 4 weeks afterward in the control(No-exercise) parkinsonian mice was unchanged.
The results of this study suggest that treadmill exercise partially prevented dopaminergic neurodegeneration in the nigrostriatal(substantia nigra, striatum, dentate gyrus) region of the Parkinson's Disease model, and this effects were may offer a potential therapeutic adjunct to current Parkinson's Disease therapies in the future.
목차
Abstract
Ⅰ. 서론
Ⅱ. 연구방법
Ⅲ. 결과 및 논의
Ⅳ. 결론
참고문헌
참고문헌 (22)
참고문헌 신청
1. [학술지(정기간행물)] - Adler CH / 2005 / Nonmotor complications in Parkinson's disease / Mov Disorder 20 Suppl 11 : S23 ~ S29
2. [학술지(정기간행물)] - Bilowit DS / 1956 / Establishing physical objectives in rehabilitation of patients with Parkinson's disease(gymnasium activities) / Physical Ther Rev 36 : 176 ~ 178
3. [학술지(정기간행물)] - Bostantjopoulou, S. / 2001 / Clinical features of parkinsonian patients with the a-synuclein (G209A) mutation / Mov. Disord. 16 : 1007 ~ 1013
4. [학술지(정기간행물)] - Brasted PJ / 1999 / Behavioural recovery following striatal transplantation: effects of postoperative training and P-zone volume / Exp Brain Res 128 : 535 ~ 538
5. [학술지(정기간행물)] - Colcher A. / 1999 / Clinical manifestations of Parkinson's disease / Med Clin North Am 83 : 327 ~ 347
2. [학술지(정기간행물)] - Bilowit DS / 1956 / Establishing physical objectives in rehabilitation of patients with Parkinson's disease(gymnasium activities) / Physical Ther Rev 36 : 176 ~ 178
3. [학술지(정기간행물)] - Bostantjopoulou, S. / 2001 / Clinical features of parkinsonian patients with the a-synuclein (G209A) mutation / Mov. Disord. 16 : 1007 ~ 1013
4. [학술지(정기간행물)] - Brasted PJ / 1999 / Behavioural recovery following striatal transplantation: effects of postoperative training and P-zone volume / Exp Brain Res 128 : 535 ~ 538
5. [학술지(정기간행물)] - Colcher A. / 1999 / Clinical manifestations of Parkinson's disease / Med Clin North Am 83 : 327 ~ 347
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UCI(KEPA) : I410-ECN-0101-2009-692-018410834