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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.12
- 수록면
- 177 - 182 (6page)
이용수
초록· 키워드
오류제보하기
Type Ⅰ Interferons (IFNs) are potent antiviral cytokines that modulate both innate immunity and adaptive immunity. Type Ⅰ IFNs are immediately induced by viral infection, and stimulate production of a broad range of gene products such as double-stranded RNA-activated protein kinase (PKR), 2’ 5’-oligoadenylate synthetase (OAS)/RNaseL and Mx GTPases. These proteins inhibit viral replication in host cells. Type Ⅰ IFNs, in turn, lead to antiviral state at early phase of viral infection. We provide an overview of the knowledge of IFN-inducible antiviral proteins conserved in vertebrates.
목차
ABSTRACT
Ⅰ. Introduction
Ⅱ. IFN-inducible gene products with antiviral effects
Ⅲ. Mx proteins are type Ⅰ IFN-inducible GTPase
Ⅳ. Genetics of Mx genes: variations in the antiviral activities of the allelic gene products
Ⅴ. Conclusion
References
참고문헌 (33)
참고문헌 신청
1. [학술지(정기간행물)] - Asano, A / 2003 / Mouse Mx2 gene: organization, mRNA expression and the role of the interferon- response promoter in its regulation / Gene 306 : 105 ~ 113
2. [학술지(정기간행물)] - Asano, A / 2002 / Polymorphisms and the antiviral property of porcine Mx1 protein / J. Vet. Med. Sci 64 : 1085 ~ 1089
3. [학술지(정기간행물)] - Balachandran, S / 1998 / Activation of the dsRNA-dependent protein kinase, PKR, induces apoptosis through FADD-mediated death signaling / EMBO J 17 : 6888 ~ 6902
4. [학술지(정기간행물)] - Di Paolo, C. / 1999 / Intramolecular backfolding of the carboxyl-terminal end of MxA protein is a prerequisite for its oligomerization / J. Biol. Chem 274 : 32071 ~ 32078
5. [학술지(정기간행물)] - Ghosh, A / 2001 / A specific isozyme of 2'-5' oligoadenylate synthetase is a dual function proapoptotic protein of the Bcl-2 family / J. Biol. Chem 276 : 25447 ~ 25455
2. [학술지(정기간행물)] - Asano, A / 2002 / Polymorphisms and the antiviral property of porcine Mx1 protein / J. Vet. Med. Sci 64 : 1085 ~ 1089
3. [학술지(정기간행물)] - Balachandran, S / 1998 / Activation of the dsRNA-dependent protein kinase, PKR, induces apoptosis through FADD-mediated death signaling / EMBO J 17 : 6888 ~ 6902
4. [학술지(정기간행물)] - Di Paolo, C. / 1999 / Intramolecular backfolding of the carboxyl-terminal end of MxA protein is a prerequisite for its oligomerization / J. Biol. Chem 274 : 32071 ~ 32078
5. [학술지(정기간행물)] - Ghosh, A / 2001 / A specific isozyme of 2'-5' oligoadenylate synthetase is a dual function proapoptotic protein of the Bcl-2 family / J. Biol. Chem 276 : 25447 ~ 25455
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UCI(KEPA) : I410-ECN-0101-2009-480-019520728