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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.12
- 수록면
- 617 - 622 (6page)
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초록· 키워드
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Carnosine is a dipeptide (β-alanyl-L-histidine) found in mammalian skeletal muscle at high concentrations. Its biological functions in the muscle include antioxidant and buffering activities. The aim of this study was to evaluate the effect of carnosine on treadmill exercise capacity in mice. Fifty-six male ICR mice were divided into four groups including the control (vehicle) and oral carnosine-treated groups at the doses of 5, 50, and 500 ㎎/㎏/day for 4 weeks. All mice were acclimated to treadmill exercise for 4 weeks by running at 20-40 ㎝/sec for 10-30 min/day. At 2 and 4 weeks, endurance running time was measured. After 4 week, the activities of citrate synthase (CS), lactate dehydrogenase (LDH), and superoxide dismutase (SOD) were determined in gatrocnemius and soleus muscles. At 2 weeks after treatments, the endurance running time in the carnosine-treated groups (50 and 500 ㎎/㎏) was significantly shorter than those in the control group (P＜0.05). However, there were no statistically differences in endurance running time at 4 weeks between the control and carnosine-treated groups. CS activity was not markedly different between the control and the carnosine-treated groups. LDH activity was significantly reduced in the carnosine-treated group (500 ㎎/㎏). SOD activity was also significantly reduced in the carnosinetreated groups (50 and 500 ㎎/㎏). These results indicate that carnosine may decrease the exercise capacity in certain physiological conditions.
목차
Materials and Methods
Results
Discussion
Acknowledgments
References
참고문헌 (34)
참고문헌 신청
1. [학술지(정기간행물)] - Apple, F.S. / 1986 / Skeletal muscle lactate dehydrogenase isozyme alterations in men and women marathon runners / J. Appl. Physiol 61 : 477 ~ 481
2. [단행본] - Astrand, P.O. / 1986 / Textbook of work physiology: physiological basis of exercise (2nd edition) / McGraw-Hill Book : 21 ~ 72
3. [학술지(정기간행물)] - Chikira, M. / 1991 / Stereospecific binding of dinuclear copper (II) complex of L-carnosine with DNA / Chem. Lett 1 : 189 ~ 190
4. [학술지(정기간행물)] - Dalrymple, R.H. / 1974 / Glycolytic enzyme activity in developing red and white muscle / J. Cell Physiol 83 : 251 ~ 257
5. [학술지(정기간행물)] - Dawson, D.M. / 1964 / Lactic dehydrogenase: function of the two types / Science 143 : 929 ~ 993
2. [단행본] - Astrand, P.O. / 1986 / Textbook of work physiology: physiological basis of exercise (2nd edition) / McGraw-Hill Book : 21 ~ 72
3. [학술지(정기간행물)] - Chikira, M. / 1991 / Stereospecific binding of dinuclear copper (II) complex of L-carnosine with DNA / Chem. Lett 1 : 189 ~ 190
4. [학술지(정기간행물)] - Dalrymple, R.H. / 1974 / Glycolytic enzyme activity in developing red and white muscle / J. Cell Physiol 83 : 251 ~ 257
5. [학술지(정기간행물)] - Dawson, D.M. / 1964 / Lactic dehydrogenase: function of the two types / Science 143 : 929 ~ 993
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