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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.12
- 수록면
- 507 - 513 (7page)
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초록· 키워드
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Serotonin transporter (5-HTT) has been considered to exist in the presynaptic membrane of the serotonin (5-HT) neurons and play an important role in the terminating the 5-HT transmission. After all, maintaining 5-HT homeostasis by returning high synaptic concentrations to normal level. This study aimed clarify whether serotonergic (5-HTergic) innervation of the spinal motoneurons was altered in ataxic pogo mice, that characterized by a failures of interlimb coordination and frequent hyperextension of hindlimb. Using by immunohistochemistry and western blotting, we observed that the density of 5-HTT immunoreactive fibers and boutons in the ventral hon of lumbar region of spinal cord was significantly increased in pogo mice than in controls (P＜0.01). Also, the 5-HTT protein was significantly increased in the only lumbar spinal cord of the ataxic pogo mice (P＜0.05). However, the ventral horn of cervical and thoracic spinal cord of the pogo mice has no difference, compared with control mice. Furthermore, 5-HTT immunoreactivity levels were no difference in dorsal horn of cervical, thoracic and lumbar division of each group spinal cords. The results suggest that an increased 5-HTergic innervation of the lumbar motoneurons might be correlated with the abnormal hindlimb extension in the ataxic mice, pogo.
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재료 및 방법
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고찰
감사의 글
참고문헌
참고문헌 (32)
참고문헌 신청
1. [학술지(정기간행물)] - Ahlemeyer, B. / 1999 / The 5-HT1A receptor agonist Bay x 3702 inhibits apoptosis induced by serum deprivation in cultured neurons / Eur. J. Pharmacol 370 (2) : 211 ~ 216
2. [학술지(정기간행물)] - Besson, J.M. / 1987 / Descending serotoninergic systems / Pain Headache 9 : 64 ~ 100
3. [학술지(정기간행물)] - Blakely, R.D / 1991 / Cloning and expression of a functional serotonin transporter from rat brain / Nature 354 (6348) : 66 ~ 70
4. [학술지(정기간행물)] - Blakely, R.D / 2000 / Biogenic amine transporters: regulation in flux / Curr. Opin. Neurobiol 10 (3) : 328 ~ 36
5. [학술지(정기간행물)] - Bose, P. / 1999 / Increase in fiber density for immunoreactive serotonin, substance P, enkephalin and thyrotropin-releasing hormone occurs during the early presymptomatic period of motoneuron disease in Wobbler mouse spinal cord ventral horn / Neurosci. Lett 260 (3) : 196 ~ 200
2. [학술지(정기간행물)] - Besson, J.M. / 1987 / Descending serotoninergic systems / Pain Headache 9 : 64 ~ 100
3. [학술지(정기간행물)] - Blakely, R.D / 1991 / Cloning and expression of a functional serotonin transporter from rat brain / Nature 354 (6348) : 66 ~ 70
4. [학술지(정기간행물)] - Blakely, R.D / 2000 / Biogenic amine transporters: regulation in flux / Curr. Opin. Neurobiol 10 (3) : 328 ~ 36
5. [학술지(정기간행물)] - Bose, P. / 1999 / Increase in fiber density for immunoreactive serotonin, substance P, enkephalin and thyrotropin-releasing hormone occurs during the early presymptomatic period of motoneuron disease in Wobbler mouse spinal cord ventral horn / Neurosci. Lett 260 (3) : 196 ~ 200
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[지상4]Heat Shock Protein 25 Expression in Pogo Mouse Cerebellum
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2006 .01
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UCI(KEPA) : I410-ECN-0101-2009-510-015707000