지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.12
- 수록면
- 273 - 280 (8page)
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초록· 키워드
오류제보하기
The single intratracheal instillation (ITI) of bleomycin (BLM) is a widely used method for inducing experimental pulmonary fibrosis in rat model. In the present study, pulmonary function tests (PFTs) of tidal volume (V<SUB>T</SUB>), minute volume (V<SUB>M</SUB>), and respiratory frequency (F<SUB>R</SUB>) have been applied to study their possibility as a tool to monitor the progress of BLM-induced lung injury in rat model. Rats were treated with a single ITI of BLM (2.5 ㎎/㎏) or saline (control). Animals were euthanized at 3, 7, 14, 21, and 28 days post-ITI. Lung toxicity effects were evaluated by inflammatory cell count, lactate dehydrogenase (LDH) activity in the bronchoalveolar lavage fluid (BALF), and light microscopic examination of lung injury. The PFT parameters were measured immediately before the animals were sacrificed. BLM treatment induced significant cellular changes in BALF-increase in number of total cells, neutrophils, and lymphocytes along with sustained increase in number of macrophages compared to the controls at days 3, 7, and 14. BALF LDH level was significantly increased compared to that in the controls up to day 14. On day 3, infiltration of neutrophils was observed in the alveolar spaces. These changes developed into marked peribronchiolar and interstitial infiltration by inflammatory cells, and extensive thickening of the interalveolar septa on day 7. At 14, 21, and 28 days, mild peribronchiolar fibrosis was observed along with inflammatory cell infiltration. The results of PFT show significant consistencies compared to the results of other toxicity tests. These data demonstrate that the most suitable time point for assessing lung fibrosis in this model is 14 days post-ITI of BLM based on the observation of fibrosis at 14, 21, and 28 days. Further, the progress of lung injury can be traced by monitoring the PFT parameters of F<SUB>R</SUB>, V<SUB>T</SUB>, and V<SUB>M</SUB>.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (36)
참고문헌 신청
Antonini, J.M , 2004 , Suppression in lung defense responses after bacterial infection in rats pretreated with different welding fumes , Toxicol. Appl. Pharmacol 200 : 206 ~ 218
Antoniou, K.M , 2003 , Interferons and their application in the diseases of the lung , Chest 123 : 209 ~ 216
Ashcroft,T , 1988 , Simple method of estimating severity of pulmonary fibrosis on a numerical scale , J. Clin. Pathol 41 : 467 ~ 470
Cortijo, J , 2001 , Attenuation by oral N-acetylcysteine of bleomycin-induced lung injury in rats , Eur. Respir. J 17 : 1228 ~ 1235
El-Medany, A , 2005 , Attenuation of bleomycin-induced lung fibrosis in rats by mesna , Eur. J. Pharmacol 509 : 61 ~ 70
Antoniou, K.M , 2003 , Interferons and their application in the diseases of the lung , Chest 123 : 209 ~ 216
Ashcroft,T , 1988 , Simple method of estimating severity of pulmonary fibrosis on a numerical scale , J. Clin. Pathol 41 : 467 ~ 470
Cortijo, J , 2001 , Attenuation by oral N-acetylcysteine of bleomycin-induced lung injury in rats , Eur. Respir. J 17 : 1228 ~ 1235
El-Medany, A , 2005 , Attenuation of bleomycin-induced lung fibrosis in rats by mesna , Eur. J. Pharmacol 509 : 61 ~ 70
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