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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.3
- 수록면
- 87 - 92 (6page)
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The primary target of US FDA-approved for the treatment of Alzheimer’s disease is the inhibition of the acetylcholinesterase, an enzyme degrading acetylcholine. In this study, we examined the synergistic or additive improving effect of the combination of green tea extract and L-theanine on the scopolamine (1 ㎎/㎏, i.p.)-induced memory dysfunction in mice since these two compounds have memory improving capability. The mice were fed drinking water containing the combination of green tea extract (24 ㎎/㎏) and L-theanine (4 ㎎/㎏) or single compound for 7 days, and scopolamine was given to mice to induce memory deficient before behavioral test. The combination of green tea extract and L-theanine more significantly inhibited the scopolamine-induced latency time and distance in the water maze test, and increased retention time in the passive avoidance test than those of single compounds. The combination of green tea extract and L-theanine more significantly inhibited acetylcholinesterase activity in the cortex and hippocampus of mice brain. This study suggests that the combination of green tea extract and Ltheanine may act synergistically, and the combination may be more useful for the prevention of progression of Alzheimer’s disease.
목차
재료 및 방법
결과
고찰
감사의 글
참고문헌
참고문헌 (23)
참고문헌 신청
1. [학술지(정기간행물)] - Borzelleca, J.F / 2006 / A 13-week dietary toxicity and toxicokinetics study with L-theanine in rat. Food Chem / Toxicol 44 (7) : 1158 ~ 1166
2. [학술지(정기간행물)] - Chow, H.H / 2003 / Pharmacokinetics and safety of green tea polyphenols after multiple-dose administration of epigallocatechin gallate andpolyphenon E in healthy individuals / Clin. Cancer Res 9 (9) : 3312 ~ 3319
3. [학술지(정기간행물)] - Ellman, G.L / 1961 / A new and rapid colorimetric determination of acetylcholinesterase activity / Biochemistry 7 : 88 ~ 95
4. [학술지(정기간행물)] - Giacobini, E / 2002 / Inhibition of acetyl- and butyryl-cholinesterase in the cerebrospinal fluid of patients with Alzheimer's disease by rivastigmine: correlation with cognitive benefit / J. Neural Transm 109 (7-8) : 1053 ~ 1065
5. [학술지(정기간행물)] - Grantham, C / 2002 / The rationale behind cholinergic drug treatment for dementia related to cerebrovascular disease / J. Neurol. Sci 2203-204 : 131 ~ 136
2. [학술지(정기간행물)] - Chow, H.H / 2003 / Pharmacokinetics and safety of green tea polyphenols after multiple-dose administration of epigallocatechin gallate andpolyphenon E in healthy individuals / Clin. Cancer Res 9 (9) : 3312 ~ 3319
3. [학술지(정기간행물)] - Ellman, G.L / 1961 / A new and rapid colorimetric determination of acetylcholinesterase activity / Biochemistry 7 : 88 ~ 95
4. [학술지(정기간행물)] - Giacobini, E / 2002 / Inhibition of acetyl- and butyryl-cholinesterase in the cerebrospinal fluid of patients with Alzheimer's disease by rivastigmine: correlation with cognitive benefit / J. Neural Transm 109 (7-8) : 1053 ~ 1065
5. [학술지(정기간행물)] - Grantham, C / 2002 / The rationale behind cholinergic drug treatment for dementia related to cerebrovascular disease / J. Neurol. Sci 2203-204 : 131 ~ 136
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
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마우스에서 L-Theanine의 기억력 회복능 및 Acetylcholinesterase 활성 억제
약학회지
2007 .01
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녹차추출물/L-Theanine 혼합물의 Secretase 활성 억제 및 세포사 억제를 통한 기억력 회복능
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약학회지
2009 .01
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Anxiolytic Effect of a Combination of Green Tea Extract and L-theanine
Laboratory Animal Research
2010 .03
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Modulation of adipogenesis and lipolysis by green tea in 3T3- Ll adipocytes
한국응용약물학회 추계학술발표논문집
2003 .01
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녹차(綠茶)추출물에 의한 치매 치료 및 예방에 관한 연구
논문집 : 대전대학교 한의학연구소. 한의학편
2003 .01
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The Chronic Administration of Green Tea Extract Affects the Memory and Brain Neurotransmitters in Senescence - accelerated Mouse
Laboratory Animal Research
2000 .09
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Inhibitiory effect of green tea extract on $A\beta$-induced PC12 cell death
대한약학회 학술대회
2003 .01
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녹차에 의한 직업성 천식 및 비염 1예
천식 및 알레르기
2009 .01
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Oxidative DNA damage by Ethanol Extract of Green Tea
한국환경성돌연변이·발암원학회지
2005 .06
-
The chronic administration of green tea extract affects the levels of brain neurotransmitters in senescence accelerated mouse
대한약학회 학술대회
2000 .01
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Scopolamine 유발 기억 손상 마우스에서 익모초의 효과
동의생리병리학회지
2020 .04
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고콜레스테롤혈증 토끼에서 녹차추출물의 동맥경화 치료효과
Laboratory Animal Research
2004 .09
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Human Skin Safety Test of Green Tea Cell Extracts in Condition of Allergic Contact Dermatitis
Toxicological Research
2012 .06
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합환피의 인지 및 기억력 개선 효과에 대한 연구
동의생리병리학회지
2017 .10
이 논문의 저자 정보
이 논문과 함께 이용한 논문
녹차에 의한 치매 치료 및 예방 연구
임종순
한국식품과학회 심포지엄
2001
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Effects of Acori Graminei Rhizoma on Scopolamine-induced Amnesia in Rats
Bo-Kyoung Pa
,
k
,
Sang-Yeon Min
외 1명
대한한의학회지
2008
.12
Anxiolytic Effect of a Combination of Green Tea Extract and L-theanine
Won Kyung Lee
,
Tae Il Kim
,
Sang-ki Pa
외 4명
Laboratory Animal Research
2010
.03
BIOLOGICAL ACTIVITIES OF L - THEANINE (SUNTHEANINE™), AN AMINO ACID OF GREEN TEA, IN HUMANS
Yutaka Ogasawa
,
a
,
Tsutomu Okubo
외 5명
한국식품영양과학회 학술대회발표집
2001
.12
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UCI(KEPA) : I410-ECN-0101-2009-510-014753599