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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2005.3
- 수록면
- 55 - 59 (5page)
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The present study was designed to investigate the chemopreventive effects of KTG075, which is a mixture of nine herbs with anti-constipation activity in Ioperamide-treated rats, on 1,2-dimethylhydrazine (DMH)-induced aberrant crypt foci (ACF) in rat colonic mucosa. KTG075 was administered in the drinking water (3.2 ㎎/㎖) during the initiation (for 12 weeks) or postinitiation phase (for 9 weeks) of DMH-induced carcinogenesis. KTG075 coupled with DMH for 12 weeks significantly decreased total number of aberrant crypts (pre-neoplastic lesions) and the number of ACF to 35% and 30%, respectively. The number of ACF with more than four aberrant crypts (crypt multiplicity) significantly reduced in the colon of rats treated with KTG075 for 12 weeks. In the group receiving KTG075 during post-initiation stage for 9 weeks, only the number of ACF with more than four aberrant crypts significantly decreased. KTG075, given alone for 12 weeks, did not induced the development of ACF. These findings indicate that KTG075 may have possess chemopreventive effects on chemically induced rat colon carcinogenesis.
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UCI(KEPA) : I410-ECN-0101-2009-510-016364761