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- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2005.3
- 수록면
- 11 - 18 (8page)
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Humanized Balb/c mice (termed Trimera mice) conditioned by lethal total body irradiation and bone marrow transplantation from NOD/SCID mice have been described to support efficient engraftment of human tissues. To evaluate the efficacy of potential anti-HBV agents in vivo, we, here, describe the development of a mouse Trimera model for human hepatitis B virus (HBV) infection. HBV viremia was induced by transplantation of ex-vivo HBV-infected human liver fragments under the kidney capsule of Trimera mice (HBV-Trimera). The levels of HBV viremia were determined by measuring serum HBV DNA using polymerase chain reaction (PCR) at 10 days after liver transplantation. In order to evaluate the therapeutic potential of two humanized monoclonal antibodies specific to hepatitis B surface antigens, the HBV-Trimera mice were administrated intraperitoneally with anti-HBs antibody (HzSIII) or anti-preS1 antibody (AP301) at days 14 to 17 post-liver transplantation. Treatment of the HBV-Trimera mice with two anti-HBV humanized monoclonal antibodies (HzSIII, AP301) reduced the viral load in their sera in a dose-dependent manner, suggesting that the humanized antibodies will be useful in the prevention and treatment of HBV infection. These results suggest that the HBV-Trimera mice can be used as an animal models for evaluating therapeutic efficacy of anti-HBV agents.
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UCI(KEPA) : I410-ECN-0101-2009-510-016364701