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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.9
- 수록면
- 271 - 275 (5page)
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This study compared the effects of high linear energy transfer (LET) fast neutrons (35 MeV) on embryotoxicity of ICR mouse exposed to low LET 60Co gamma-rays. At 11.5 days after conception, pregnant mice were exposed to 0-4 Gy of gamma-rays or 0-1.6 Gy of neutrons. The animals were sacrificed on day 18 of gestation and the fetuses were examined for mortality, growth retardation, change in head size and any other morphological abnormalities. With increasing radiation dose, incidence of small head, growth retarded fetuses, cleft palate, dilatation of cerebral ventricle and abnormalities of the extremities in live fetuses rose. Neutron irradiation produced a greater proportion of offspring with very low body weight than with malformations when compared to gamma-rays. In the malformation frequency between 30% and 70%, the relative biological effectiveness (RBE) of the neutrons was 2.14 ± 0.48. These results indicate that the embryo exhibits a linear response to increasing doses of neutrons during the period of major organogenesis.
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감사의 글
참고문헌
참고문헌 (28)
참고문헌 신청
Aolad, H.M , 2000 , Hydrocephalus in mice following X-irradiation at early gestational stage: possible due to persistent deceleration of cell proliferation 41 : 213 ~ 226
Beir,V , 1990 , Health effects of exposure to low levels of ionizing radiation. In Biological effects of ionizing radiations. pp. 22-45
Brent , 1984 , The effects of ionizing radiation and ultrasound on the developing embryo Clinical interpretations and applications of the data. Curr. Proble. Pediatr. 14 : 1 ~ 87
Britten, R.A , 2001 , Biological factors influencing the RBE of neutrons: implications for their past, present and future use in radiotherapy 156 : 125 ~ 135
E , 1985a , Effects of dietary supplementation with selenomethionine on the teratogenic effect of ionizing radiation in mice. Acta Radiol. Oncol. 24 : 459 ~ 463
Beir,V , 1990 , Health effects of exposure to low levels of ionizing radiation. In Biological effects of ionizing radiations. pp. 22-45
Brent , 1984 , The effects of ionizing radiation and ultrasound on the developing embryo Clinical interpretations and applications of the data. Curr. Proble. Pediatr. 14 : 1 ~ 87
Britten, R.A , 2001 , Biological factors influencing the RBE of neutrons: implications for their past, present and future use in radiotherapy 156 : 125 ~ 135
E , 1985a , Effects of dietary supplementation with selenomethionine on the teratogenic effect of ionizing radiation in mice. Acta Radiol. Oncol. 24 : 459 ~ 463
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p53 and Cell Cycle-Regulated Protein Expression in Small Intestinal Cells after Fast Neutron Irradiation in Mice
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Lack of Adaptive Response of Gamma Radiation for Protection against Neutron-induced Teratogenesis
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The Combined Effect of Fast Neutron and Hyperthermia according to the Sequence and Interval in MKN-45 Cells
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MC50 싸이클로트론에서 생성되는 중성자선의 생물학적 특성의 평가
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The RBE of Fast Neutrons versus ⁶⁰CO γ -Rays for Apoptosis induction in mouse crypt cells
Laboratory Animal Research
2001 .03
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The RBE of Fractionated Fast Neutron on Walker 256 Carcinosarcoma with KCCH-Cyclotron
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1987 .01
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Chronic effects of hair, blood and testis in black mouse with neutron Irradiation by lying flat pose
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2004 .05
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방사선 조사 마우스에서 오가피의 면역활성 효과
동의생리병리학회지
2006 .01
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UCI(KEPA) : I410-ECN-0101-2009-510-016364221