지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2006.12
- 수록면
- 389 - 395 (7page)
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초록· 키워드
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Cardiac hypertrophy, or an increase in heart size, is an important risk factor for cardiac morbidity and mortality. Epigallocathechin-3 gallate (EGCG) is one of major bioactive polyphenols present in green tea and believed to ameliorate cardiovascular disease. Therefore, we investigated whether EGCG and green tea extract (GTE) supplementation could attenuate the development of cardiac hypertrophy induced by volume overload. Cardiac hypertrophy was induced by aortocaval shunt (ACS) in rats and evaluated by determining the heart to body weight (HW/BW) ratio or cross sectional area. Cardiac hypertrophy induced by ACS for 3 weeks was significantly attenuated by administration of EGCG or GTE. Attenuation of cardiac hypertrophy by EGCG was associated with attenuation of the increase' in myocyte cell size induced by volume overload. Hypertrophied hearts are known to be vulnerable to ischemia. EGCG or GTE administration not only inhibited cardiac hypertrophy but also enhanced cardiac function during ischemia reperfusion injury. These results suggest that EGCG prevent the development of cardiac hypertrophy due to volume overload and may be a useful therapeutic modality to suppress cardiac hypertrophy in patients.
목차
Materials and Methods
Results
Discussion
Acknowledgments
References
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UCI(KEPA) : I410-ECN-0101-2009-510-016363193