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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2006.9
- 수록면
- 289 - 293 (5page)
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Di-isodecyl phthalate (DIDP) has widely used as plasticizer in polyvinyl chloride (PVC) manufacture and ultimately typical vinyl applications, particularly wire, cable and toys. To determine dose selection of DIDP for alternative carcinogenicity study using ras H2 transgenic mice, we conducted four week repeated toxicity study with ras H2 wild type mice. Groups of 8 male and female ras H2 wild type mice were fed basal diet containing DIDP at doses of 0, 0.1, 0.3, 1, and 3% for 4 weeks. Decreases of motility and mortality were increased in the 3% DIDP treatment group. The body weights of 3% DIDP treatment group were significantly decreased compared to those of control group. The relative liver weights of male and female mice given 0.3 and 1% DIDP were significantly increased compared to those of control. At necropsy, there were no significant changes in gross lesions between treatment and control group. Microscopically, the incidences of hypertrophy of liver in mice exposed to 1 and 3% DIDP treatment groups were increased. These results indicate that DIDP has liver toxicity at greater than 1% dose. Therefore, maximum tolerated dose (MTD) was determined for each biological endpoints at a dietary level of 1%.
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UCI(KEPA) : I410-ECN-0101-2009-510-016356050