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The cholesterol-lowering and antiatherosclerotic effects of Mori radicis cortex-water extracts (MRC-WE) in hypercholesterolemic rabbits were investigated. Male New Zealand white rabbits were fed a high-cholesterol diet containing 1% cholesterol and 2% corn oil for 2 weeks, and then MRC-WE (1% or 3%) or lovastatin (0.002%) were added to the diet for additional 8 weeks. The levels of blood cholesterol, low-density lipoproteins (LDL) and high-density lipoproteins (HDL) were greatly increased by 2-week feeding the high-cholesterol diet, compared with those of animals fed normal diet. Blood concentrations of cholesterol, LDL and triglycerides further increased during additional 8-week feeding the high-cholesterol diet alone, in contrast to significant decrease in HDL level. In comparison, the levels of cholesterol and LDL were reduced by lovastatin and MRC-WE (1%), in addition to less-severe decrease in HDL contents. In addition, lovastatin and MRC-EE (1%) lowered lipid deposition in hepatocytes, showing restricted distribution of foamy hepatocytes. The thick atheromatous plaques (mean score 2.75) on the aortic wall of rabbits fed the high-cholesterol diet were markedly attenuated by lovastatin or MRC-WE (1%), leading to the decrease in athrosclerosis indices to 2.0 and 2.25, respectively. It is suggested that a low level (1%) of MRC-WE exerts antiatherosclerotic effect by reducing blood cholesterol and LDL.

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UCI(KEPA) : I410-ECN-0101-2009-510-016362803