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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.12
- 수록면
- 471 - 475 (5page)
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The strain of rasH2 mice carrying human c-Ha-ras gene had been developed to use for rapid carcinogenicity testing. The mice develops various kinds of tumors including lymphoma when induced by carcinogen N-methyl-N-nitrosourea (MNU). In this study, 30 rasH2-Tg mice were treated with 75 ㎎/㎏ of MNU to induce lymphoma in 26 weeks. A total of 22 mice (13 male, 9 female) developed lymphoma. Immunohistochemistry for localization of cell surface antigens were performed to subclassify the lymphomas. Antibodies against BOB.1 and oct-2 were applied for B cell lymphoma and CD3 for T cell lymphoma. In T cell lymphoma, CD3 were expressed in cytoplasmic membranes of most tumor cells, whereas oct-2 and BOB.1 were localized in some cells in B cell lymphoma. Most of lymphomas cases expressed T cell marker CD3. The reason T cell lymphomas so frequently developed in rasH2 mice by MNU treatment should be further elucidated.
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참고문헌 (28)
참고문헌 신청
1. [학술지(정기간행물)] - Aquino / 1993 / is a major constituent of the central nervous system and is up-regulated only at the mRNA level in acute experimental autoimmune encephalomyelitis : 1340 ~ 1348
2. [학술지(정기간행물)] - Armstrong, C.L / 2000 / Constitutive expression of the 25 kDa heat shock protein HSP25 reveals novel parasagittal bands of Purkinje cells in the adult mouse cerebellar cortex 416 : 383 ~ 397
3. [학술지(정기간행물)] - Armstrong, C.L / 2001 / Constitutive expression of heat shock protein HSP25 in the central nervous system of the developing and adult mouse 434 : 262 ~ 274
4. [학술지(정기간행물)] - Haye / 1994 / Phosphorylation and supramolecular organization of murine small heat shock protein HSP25 abolish its actin polymerization-inhibiting activity : 20780 ~ 200784
5. [학술지(정기간행물)] - Blake / 1990 / In vivo hyperthermia induces expression of HSP70 mRNA in brain regions controlling the neuroendocrine response to stress : 89 ~ 92
2. [학술지(정기간행물)] - Armstrong, C.L / 2000 / Constitutive expression of the 25 kDa heat shock protein HSP25 reveals novel parasagittal bands of Purkinje cells in the adult mouse cerebellar cortex 416 : 383 ~ 397
3. [학술지(정기간행물)] - Armstrong, C.L / 2001 / Constitutive expression of heat shock protein HSP25 in the central nervous system of the developing and adult mouse 434 : 262 ~ 274
4. [학술지(정기간행물)] - Haye / 1994 / Phosphorylation and supramolecular organization of murine small heat shock protein HSP25 abolish its actin polymerization-inhibiting activity : 20780 ~ 200784
5. [학술지(정기간행물)] - Blake / 1990 / In vivo hyperthermia induces expression of HSP70 mRNA in brain regions controlling the neuroendocrine response to stress : 89 ~ 92
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UCI(KEPA) : I410-ECN-0101-2009-510-016250079