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논문 기본 정보

자료유형
학술저널
저자정보
저널정보
한국체육과학회 한국체육과학회지 한국체육과학회지 제16권 제3호
발행연도
2007.8
수록면
547 - 557 (11page)

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초록· 키워드

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The purpose of this study was to investigate the effect of regular aerobic exercise and DL-α-lipoic acid(ALA) supplementation for 8 weeks on Hydrogen peroxide, MDA and Vitamin E concentrations and caspase-3 activity in induced aging rats heart by D-galactose ingestion(50mg/kg). The rats were randomly assigned to one of the following four groups(n=8 per group): 1) control group(CON) 2) aging control group(A-CON) 3) aging exercise group(A-EX) 4) ALA supplementation group(A-ALA) 5) exercise training with ALA supplementation group(A-EA). Ageing rats were induced by injecting D-galactose(50mg/kg dissolved in 0.1ml dilution water) every day for 8 weeks excluding control group. ALA(100mg/kg) was supplemented orally every day for 8 weeks. The exercise program regime consisted of running on a treadmill at an increasing pace. Hydrogen peroxide and MDA concentrations were significantly lower in the A-EX, A-ALA, A-EA groups compared with A-CON group. Vitamin E concentration was significantly lower in the A-EA groups compared with other groups, but not GSSG level. Caspase-3 activity was significantly decrease in the A-ALA, A-EA groups compared with other groups, and caspase-3 activity in A-ALA, A-EA groups was similar with CON group. These results suggest that regular exercise combined with ALA supplementation can offer beneficial effects of prevent lipid peroxidation and apoptosis in D-galactose induced aging rats heart.

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Abstract
Ⅰ. 서론
Ⅱ. 연구방법
Ⅲ. 결과
Ⅳ. 논의
Ⅴ. 결론
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UCI(KEPA) : I410-ECN-0101-2009-692-016097764