지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 연구보고서
- 저자정보
- 발행연도
- 2006.12
- 수록면
- 214 - 219 (36page)
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초록· 키워드
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To date diabetic nephropathy is believed to be the consequence of progressive T cell-mediated autoimmune destruction of kidney cells. The generation of free radicals in target cells has been also implicated as one of the various mechanisms involved in the destruction of kidney cells.
The objectives of this research are to screen oriental medicinal herbs for the treatment of diabetic nephropathy and investigate mechanism by which high glucose destruct kidney cells.
To develop drugs for the treatment of diabetic nephropathy, we first screened for the activities of nitric oxide (NO) synthesis from oriental medicinal herbs. NO participates in the inflammatory response of macrophages and plays important roles in the destruction of pancreatic beta cells and kidney cells (Hibbs et al., 1987). The positive fractions were then further analyzed for the NO inhibition by dose-response study. We screened 380 herbs and confirmed 13 positive fractions. We investigated the effect of the combined extracts (KIOM-79) isolated from Magnolia officinalis, Pueraria lcbata, Glycyrrhiza uralensis, and Euphorbia pekinensis on the production of NO. To further investigate the mechanism by which KIOM-79 inhibits the expression of iNOS gene, we assessed the effects of KIOM-79 on the activation of NF-кB. The present studies demonstrate that KIOM-79 inhibits iNOS gene expression through the inhibition of NF-KB. KIOM-lO also inhibited iNOS gene expression by blocking NF-KB and p38 kinase activation. We found that high glucose demage kidney cells and inhibits the activities of membrane transporters. We also found that NF-кB and protein kinase C are potential targets for high glucose treatment.
Successive results of this project will contribute to studies involved in the pathogenesis of diabetic nephropathy, the development of new anti-diabetic drugs, and the action mechanisms of the drugs. The immunosupressive medicinal herbs selected by the screening will be used to test the possibilities for drugs against diseases (other autoimmune diseases, skin aging, or cancer) as well as insulin-dependent Diabetes mellitus. Products from the project such as, screening system and positive fractions of the herbs can be used to study medicine, pharmacology, and biology.
The objectives of this research are to screen oriental medicinal herbs for the treatment of diabetic nephropathy and investigate mechanism by which high glucose destruct kidney cells.
To develop drugs for the treatment of diabetic nephropathy, we first screened for the activities of nitric oxide (NO) synthesis from oriental medicinal herbs. NO participates in the inflammatory response of macrophages and plays important roles in the destruction of pancreatic beta cells and kidney cells (Hibbs et al., 1987). The positive fractions were then further analyzed for the NO inhibition by dose-response study. We screened 380 herbs and confirmed 13 positive fractions. We investigated the effect of the combined extracts (KIOM-79) isolated from Magnolia officinalis, Pueraria lcbata, Glycyrrhiza uralensis, and Euphorbia pekinensis on the production of NO. To further investigate the mechanism by which KIOM-79 inhibits the expression of iNOS gene, we assessed the effects of KIOM-79 on the activation of NF-кB. The present studies demonstrate that KIOM-79 inhibits iNOS gene expression through the inhibition of NF-KB. KIOM-lO also inhibited iNOS gene expression by blocking NF-KB and p38 kinase activation. We found that high glucose demage kidney cells and inhibits the activities of membrane transporters. We also found that NF-кB and protein kinase C are potential targets for high glucose treatment.
Successive results of this project will contribute to studies involved in the pathogenesis of diabetic nephropathy, the development of new anti-diabetic drugs, and the action mechanisms of the drugs. The immunosupressive medicinal herbs selected by the screening will be used to test the possibilities for drugs against diseases (other autoimmune diseases, skin aging, or cancer) as well as insulin-dependent Diabetes mellitus. Products from the project such as, screening system and positive fractions of the herbs can be used to study medicine, pharmacology, and biology.
목차
[요약문]
SUMMARY
제1장 연구제목
제2장 연구개발의 목적 및 필요성
제3장 연구개발의 내용 및 범위
제4장 연구 개발 결과
제5장 연구개발결과의 활용계획
제6장 참고문헌
참고문헌 (0)
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UCI(KEPA) : I410-ECN-0101-2009-519-016568282