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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 연구보고서
- 저자정보
- 발행연도
- 2006.12
- 수록면
- 1 - 101 (101page)
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초록· 키워드
오류제보하기
If herbal medicine has not stored properly during its manufacturing, processing and distributing processes, it was changed in quality or deterioration from high possibility of microbial growth and contaminant ultimately bring about the reduced quality in herbal medicine.
This study was attempted to establish an organized system for storage standards by 1) monitoring microbial contamination (total bacteria, total fungi, E. coli, salmonella, P. aeruginosa, S. aureus) of distributed materials from herbal medicine (10 species, 50 samples) 2) analyzing the quality variation of the main component and microbial contamination by storage factors (temperature, packing materials, periods) 3) quality monitoring of distributed materials (2 species, 50 samples) according to storage periodsl l year, 2 year, 3 year).
The changes of loss on drying contents, component assay by HPLC method, and microbial contamination test were measured during storage.
The levels of microbial contamination in the 50 samples herbal medicines were investigated by using selective media of total bacteria, total fungi, E. coli, salmonella, P. aeruginosa, S. aureus, in accordance with testing method of Korea Pharmacopoeia 8th edition.
As a result, the microbial contamination of 50 items were showed that total fungi count on Atractylodis Rhizornatd items) showed as high measured by WHO's microbial contamination limit standard.
Among the total 50 herbal medicines, 12 presumptively E. coli were isolated and identified as E. colic). strain), coliform bacteria(11 strains). 21 presumptively S. aureus were isolated and identified but it was not detected. whereas presumptively salmonella and P. aeruginosa were not detected at all samples.
Quality changes by storage conditions were showed that the remarkable content change of poncirin, magnolol, honokiol was founded after 12 month stored whreas change of cinnamic acid, berberine were appeared uniformly.
This study was attempted to establish an organized system for storage standards by 1) monitoring microbial contamination (total bacteria, total fungi, E. coli, salmonella, P. aeruginosa, S. aureus) of distributed materials from herbal medicine (10 species, 50 samples) 2) analyzing the quality variation of the main component and microbial contamination by storage factors (temperature, packing materials, periods) 3) quality monitoring of distributed materials (2 species, 50 samples) according to storage periodsl l year, 2 year, 3 year).
The changes of loss on drying contents, component assay by HPLC method, and microbial contamination test were measured during storage.
The levels of microbial contamination in the 50 samples herbal medicines were investigated by using selective media of total bacteria, total fungi, E. coli, salmonella, P. aeruginosa, S. aureus, in accordance with testing method of Korea Pharmacopoeia 8th edition.
As a result, the microbial contamination of 50 items were showed that total fungi count on Atractylodis Rhizornatd items) showed as high measured by WHO's microbial contamination limit standard.
Among the total 50 herbal medicines, 12 presumptively E. coli were isolated and identified as E. colic). strain), coliform bacteria(11 strains). 21 presumptively S. aureus were isolated and identified but it was not detected. whereas presumptively salmonella and P. aeruginosa were not detected at all samples.
Quality changes by storage conditions were showed that the remarkable content change of poncirin, magnolol, honokiol was founded after 12 month stored whreas change of cinnamic acid, berberine were appeared uniformly.
목차
제1장 연구개발의 목적 및 필요성
제2장 연구개발의 내용 및 범위
제3장 연구개발방법 및 결과
제4장 결론
제5장 참고문헌
요약문
Summary
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UCI(KEPA) : I410-ECN-0101-2009-519-016568171