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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Acori graminei Rhizoma (AGR) is a perennial herb which has been used clinically as a traditional oriental medicine against stroke, Alzheimer’s disease, and vascular dementia. We investigated the effect of AGR on the modulation of gene expression profile in a hypoxic model of cultured rat cortical cells. Rat cerebrocortical cells were grown in Neurobasal medium. On DIV12, cells were treated with AGR (10 ㎍/㎖), given a hypoxic shock (2% O₂, 3 hr) on DIV14, and total RNAs were prepared one day after shock. Microarray analyses indicated that the expression levels of most genes were altered within the global M values +0.5 and -0.5, i.e., 40% increase or decrease. There were 750 genes which were upregulated by ＜ global M +0.2, while 700 genes were downregulated by ＞ global M -0.2. The overall profile of gene expression suggests that AGR suppresses apoptosis (upregulation of anti-apopotic genes such as TEGT, TIEG, Dad, p53, and downregulation of pro-apopotic genes such as DAPK, caspase 2, pdcd8), ROS (upregulation of RARα, AhR), and that AGR has neurotrophic effects (upregulation of Akt1, Akt2). These results provide a platform for investigation of the molecular mechanism of the effect of AGR in neuroprotection.
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재료 및 방법
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참고문헌
참고문헌 (58)
참고문헌 신청
Ashktorab, H., A. Ahmed, G. Littleton, X. W. Wang, C. R. Allen, R. Tackey, C. Walters and D. T. Smoot. 2003. p53 and p14 increase sensitivity of gastric cells to H. pylori-induced apoptosis. Dig Dis Sci. 48, 1284-1291.
Banasiak, K. J. and G. G. Haddad. 1998. Hypoxia-induced apoptosis: effect of hypoxic severity and role of p53 in neuronal cell death. Brain Res. 797, 295-304.
Barks, J.D. and F. S. Silverstein. 1992. Excitatory amino acids contribute to the pathogenesis of perinatal hypoxic-ischemic brain injury. Brain Pathol. 235-243.
Beilharz, E. J. and C. E. Williams, M. Dragunow, E. S. Sirmanne and P. D. Gluckman. 1995. Mechanisms of delayed cell death following hypoxic-ischemic injury in the immature rat: evidence for apoptosis during selective neuronal loss. Mol Brain Res. 29, 1-1
Besnard, S., C. Heymes, R. Merval, M. Rodriguez, J. P. Galizzi, J. A. Boutin, J. Mariani and A. Tedgui. 2002. Expression and regulation of the nuclear receptor RORalpha in human vascular cells. FEBS Lett. 511, 36-40.
Banasiak, K. J. and G. G. Haddad. 1998. Hypoxia-induced apoptosis: effect of hypoxic severity and role of p53 in neuronal cell death. Brain Res. 797, 295-304.
Barks, J.D. and F. S. Silverstein. 1992. Excitatory amino acids contribute to the pathogenesis of perinatal hypoxic-ischemic brain injury. Brain Pathol. 235-243.
Beilharz, E. J. and C. E. Williams, M. Dragunow, E. S. Sirmanne and P. D. Gluckman. 1995. Mechanisms of delayed cell death following hypoxic-ischemic injury in the immature rat: evidence for apoptosis during selective neuronal loss. Mol Brain Res. 29, 1-1
Besnard, S., C. Heymes, R. Merval, M. Rodriguez, J. P. Galizzi, J. A. Boutin, J. Mariani and A. Tedgui. 2002. Expression and regulation of the nuclear receptor RORalpha in human vascular cells. FEBS Lett. 511, 36-40.
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UCI(KEPA) : I410-ECN-0101-2009-470-017681404