지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2006.6
- 수록면
- 93 - 103 (11page)
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초록· 키워드
오류제보하기
Objectives : The aims of this study were to know the frequency of white matter lesions(WMLs) on brain magnetic resonance imaging(MRI) in patients with mild cognitive impairment(MCI), and to identify related factors.
Methods : Among WMLs, periventricular hyperintensities(PVHs) and deep white matter hyperintensities(DWMHs) on brain MRI in patients with MCI(N=30), patients with dementia of the Alzheimer's type (DAT)(N=34) and normal aged controls(N=20) were analyzed. Furthermore, related variables including cardiovascular risk factors were discussed.
Results : 1) The frequencies of the third degree PVHs in patients with MCI(16.6%) were significantly different from those of normal aged controls(5.0%), and from those of patients with DAT(38.2%)(p＜0.05). However, frequencies of the third degree DWMHs in patients with MCI(23.3%) were not different from those of normal aged controls(10.0%), and from those of patients with DAT(35.3%). 2) The frequencies of various cardiovascular risk factors in patients with MCI, patients with DAT and normal aged controls were not significantly different. 3) The severity of PVLs seemed to be related to age(p＜0.05), systolic blood pressure(p＜0.05) and diastolic blood pressure(p＜0.005). The severity of DWMHs were seemed to be related to sex(p＜0.05), education(p＜0.05), Global Deterioration Scale(p＜0.05), systolic blood pressure(p＜0.01) and diastolic blood pressure(p＜0.05).
Conclusion : The PVHs might be useful to discriminate patients with MCI from normal aged person. Active management of hypertension seemed to be crucial to prevent from development of WMLs.
Methods : Among WMLs, periventricular hyperintensities(PVHs) and deep white matter hyperintensities(DWMHs) on brain MRI in patients with MCI(N=30), patients with dementia of the Alzheimer's type (DAT)(N=34) and normal aged controls(N=20) were analyzed. Furthermore, related variables including cardiovascular risk factors were discussed.
Results : 1) The frequencies of the third degree PVHs in patients with MCI(16.6%) were significantly different from those of normal aged controls(5.0%), and from those of patients with DAT(38.2%)(p＜0.05). However, frequencies of the third degree DWMHs in patients with MCI(23.3%) were not different from those of normal aged controls(10.0%), and from those of patients with DAT(35.3%). 2) The frequencies of various cardiovascular risk factors in patients with MCI, patients with DAT and normal aged controls were not significantly different. 3) The severity of PVLs seemed to be related to age(p＜0.05), systolic blood pressure(p＜0.05) and diastolic blood pressure(p＜0.005). The severity of DWMHs were seemed to be related to sex(p＜0.05), education(p＜0.05), Global Deterioration Scale(p＜0.05), systolic blood pressure(p＜0.01) and diastolic blood pressure(p＜0.05).
Conclusion : The PVHs might be useful to discriminate patients with MCI from normal aged person. Active management of hypertension seemed to be crucial to prevent from development of WMLs.
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UCI(KEPA) : I410-ECN-0101-2009-513-017222032